Bone-targeting radiopharmaceuticals for the treatment of prostate cancer with bone metastases

Jatinder Goyal, Emmanuel S. Antonarakis

Research output: Contribution to journalReview article

Abstract

Patients with castration-resistant prostate cancer (CRPC) frequently have metastases to the bone, which may cause pain and lead to a deterioration in quality-of-life. Bone-seeking radiopharmaceuticals are agents which, when administered systemically, localize to the site of bone metastases and deliver focal radiation there. In this review, we will summarize the current literature on bone-targeting radiopharmaceuticals for CRPC, focusing on strontium-89, samarium-153, rhenium-186 and radium-223. We will discuss their indications, clinical efficacy, and toxicities and highlight some of the challenges in optimizing treatment with these agents. Historically, clinical trials with these drugs have failed to demonstrate survival improvements, restricting their use for palliative purposes only. Radium-223 is the first agent in this class to show an overall survival advantage in CRPC patients with bone metastases. This landmark finding will likely have a considerable impact on the treatment paradigm of bone-metastatic CRPC, and will pave the way for further developments in the future.

Original languageEnglish (US)
Pages (from-to)135-146
Number of pages12
JournalCancer Letters
Volume323
Issue number2
DOIs
StatePublished - Oct 28 2012

Keywords

  • Bone metastases
  • Castration-resistant prostate cancer
  • Radiopharmaceuticals
  • Radium-223
  • Samarium-153
  • Strontium-89

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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