Bone mineral status in prepubertal children with cystic fibrosis

Linda A. Mortensen, Gary M. Chan, Stephen C. Alder, Bruce Marshall

Research output: Contribution to journalArticle

Abstract

Objectives: To determine whether osteopenia is evident in prepubertal children with cystic fibrosis (CF) and, if so, whether it is caused by a deficiency in bone formation or increased bone resorption. Study design: With the use of a prospective case control study design, we investigated 11 prepubertal children with CF between the ages of 8 and 12 years old and a non-CF control group matched by weight and sex. Bone density at the radius, ulnar, trochanter, femoral neck, and lumbar spine, biochemical markers of bone metabolism, calcium, vitamin D metabolites, and intact parathyroid hormone were measured in all subjects. Comparisons between the 2 groups were performed with Wilcoxon matched pairs and Fisher exact tests. Results: Intake of total calories, calcium, phosphorus, and vitamin D was significantly greater in the CF group than in the control group. Serum 25(OH)vitamin D levels were significantly lower in the CF group: median 22 ng/mL for the CF group and 39 ng/mL for the control group (P = .02). 1,25(OH)2 vitamin D levels were borderline or low in 7 subjects in the CF group and 2 members of the control group (P = .08, Fisher exact test). Intact parathyroid hormone levels were higher than the upper limit of normal in 4 subjects of the CF group and 1 member of the control group. Despite these biochemical abnormalities, we found no evidence of bone mineral deficiency in the CF group. Conclusions: Prepubertal children with CF do not have bone mineral deficit compared with a weight- and sex-matched control group; however, their lower vitamin D levels may portend problems with bone mineralization during adolescence and adulthood.

Original languageEnglish (US)
Pages (from-to)648-652
Number of pages5
JournalJournal of Pediatrics
Volume136
Issue number5
StatePublished - 2000
Externally publishedYes

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Cystic Fibrosis
Minerals
Bone and Bones
Vitamin D
Control Groups
Parathyroid Hormone
Calcium
Ergocalciferols
Weights and Measures
Physiologic Calcification
Metabolic Bone Diseases
Femur Neck
Bone Resorption
Osteogenesis
Bone Density
Femur
Phosphorus
Case-Control Studies
Spine
Fibrosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Mortensen, L. A., Chan, G. M., Alder, S. C., & Marshall, B. (2000). Bone mineral status in prepubertal children with cystic fibrosis. Journal of Pediatrics, 136(5), 648-652.

Bone mineral status in prepubertal children with cystic fibrosis. / Mortensen, Linda A.; Chan, Gary M.; Alder, Stephen C.; Marshall, Bruce.

In: Journal of Pediatrics, Vol. 136, No. 5, 2000, p. 648-652.

Research output: Contribution to journalArticle

Mortensen, LA, Chan, GM, Alder, SC & Marshall, B 2000, 'Bone mineral status in prepubertal children with cystic fibrosis', Journal of Pediatrics, vol. 136, no. 5, pp. 648-652.
Mortensen, Linda A. ; Chan, Gary M. ; Alder, Stephen C. ; Marshall, Bruce. / Bone mineral status in prepubertal children with cystic fibrosis. In: Journal of Pediatrics. 2000 ; Vol. 136, No. 5. pp. 648-652.
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