TY - JOUR
T1 - Bone mineral status in prepubertal children with cystic fibrosis
AU - Mortensen, Linda A.
AU - Chan, Gary M.
AU - Alder, Stephen C.
AU - Marshall, Bruce C.
N1 - Funding Information:
Snpported by Public Health Services research grant number M01-RR00064 from the National Center tot Research Resources. Submitted for publication Apr 26, 1999; revision received Sept 27, 1999; accepted Oct 28, 1999. Reprint requests: Linda A. Mortensen, APRN, Department of Internal Medicine, School of Medicine, Room 4C103, University of Utah Medical Center, 50 North Medical Dr, Salt Lake City, UT 84132. Copyright O 2000 by Mosby, Inc. 0022-3476/2000/$12.00 + 0 9/21/104271 doi: 10.1067/mpd.2000.104271 population continues to grow, osteoporosis will become an increasingly important clinical problem.
PY - 2000
Y1 - 2000
N2 - Objectives: To determine whether osteopenia is evident in prepubertal children with cystic fibrosis (CF) and, if so, whether it is caused by a deficiency in bone formation or increased bone resorption. Study design: With the use of a prospective case control study design, we investigated 11 prepubertal children with CF between the ages of 8 and 12 years old and a non-CF control group matched by weight and sex. Bone density at the radius, ulnar, trochanter, femoral neck, and lumbar spine, biochemical markers of bone metabolism, calcium, vitamin D metabolites, and intact parathyroid hormone were measured in all subjects. Comparisons between the 2 groups were performed with Wilcoxon matched pairs and Fisher exact tests. Results: Intake of total calories, calcium, phosphorus, and vitamin D was significantly greater in the CF group than in the control group. Serum 25(OH)vitamin D levels were significantly lower in the CF group: median 22 ng/mL for the CF group and 39 ng/mL for the control group (P = .02). 1,25(OH)2 vitamin D levels were borderline or low in 7 subjects in the CF group and 2 members of the control group (P = .08, Fisher exact test). Intact parathyroid hormone levels were higher than the upper limit of normal in 4 subjects of the CF group and 1 member of the control group. Despite these biochemical abnormalities, we found no evidence of bone mineral deficiency in the CF group. Conclusions: Prepubertal children with CF do not have bone mineral deficit compared with a weight- and sex-matched control group; however, their lower vitamin D levels may portend problems with bone mineralization during adolescence and adulthood.
AB - Objectives: To determine whether osteopenia is evident in prepubertal children with cystic fibrosis (CF) and, if so, whether it is caused by a deficiency in bone formation or increased bone resorption. Study design: With the use of a prospective case control study design, we investigated 11 prepubertal children with CF between the ages of 8 and 12 years old and a non-CF control group matched by weight and sex. Bone density at the radius, ulnar, trochanter, femoral neck, and lumbar spine, biochemical markers of bone metabolism, calcium, vitamin D metabolites, and intact parathyroid hormone were measured in all subjects. Comparisons between the 2 groups were performed with Wilcoxon matched pairs and Fisher exact tests. Results: Intake of total calories, calcium, phosphorus, and vitamin D was significantly greater in the CF group than in the control group. Serum 25(OH)vitamin D levels were significantly lower in the CF group: median 22 ng/mL for the CF group and 39 ng/mL for the control group (P = .02). 1,25(OH)2 vitamin D levels were borderline or low in 7 subjects in the CF group and 2 members of the control group (P = .08, Fisher exact test). Intact parathyroid hormone levels were higher than the upper limit of normal in 4 subjects of the CF group and 1 member of the control group. Despite these biochemical abnormalities, we found no evidence of bone mineral deficiency in the CF group. Conclusions: Prepubertal children with CF do not have bone mineral deficit compared with a weight- and sex-matched control group; however, their lower vitamin D levels may portend problems with bone mineralization during adolescence and adulthood.
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U2 - 10.1067/mpd.2000.104271
DO - 10.1067/mpd.2000.104271
M3 - Article
C2 - 10802498
AN - SCOPUS:0034036069
SN - 0022-3476
VL - 136
SP - 648
EP - 652
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 5
ER -