Abstract
A variety of clinical and experimental reports have shown the interdependence between bone marrow and autoimmune diseases. Autoimmune diseases can be transferred as well as cured by hone marrow transplantation (BMT). The widespread application of this therapeutic approach is limited today by the morbidity and mortality associated with BMT, including failure of engraftment, graft-versus-host disease (GVHD) and the toxicity from lethal conditioning approaches. Mixed chimerism (with the advantage of superior immunocompetence of the host and a relative protection against GVHD) can be achieved with incomplete ablation conditioning regimens. BMT may provide a potential strategy to treat those autoimmune diseases for which today only symptomatic treatment is available.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 171-176 |
| Number of pages | 6 |
| Journal | Stem Cells |
| Volume | 15 |
| Issue number | SUPPL. 1 |
| State | Published - 1997 |
| Externally published | Yes |
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Keywords
- Autoimmunity
- Bone marrow transplantation
- Chimerism
- Conditioning
- Diabetes
- Facilitating cell
- NOD
ASJC Scopus subject areas
- Cell Biology
Cite this
Bone marrow transplantation for therapy in autoimmune disease. / Exner, B. G.; Groninger, J. H.; Ildstad, S. T.; Sharkis, S. J.; Kolb, H. J.; Zanjani, E. D.; Quesenberry, P. J.; Torok-Storb, B.
In: Stem Cells, Vol. 15, No. SUPPL. 1, 1997, p. 171-176.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bone marrow transplantation for therapy in autoimmune disease
AU - Exner, B. G.
AU - Groninger, J. H.
AU - Ildstad, S. T.
AU - Sharkis, S. J.
AU - Kolb, H. J.
AU - Zanjani, E. D.
AU - Quesenberry, P. J.
AU - Torok-Storb, B.
PY - 1997
Y1 - 1997
N2 - A variety of clinical and experimental reports have shown the interdependence between bone marrow and autoimmune diseases. Autoimmune diseases can be transferred as well as cured by hone marrow transplantation (BMT). The widespread application of this therapeutic approach is limited today by the morbidity and mortality associated with BMT, including failure of engraftment, graft-versus-host disease (GVHD) and the toxicity from lethal conditioning approaches. Mixed chimerism (with the advantage of superior immunocompetence of the host and a relative protection against GVHD) can be achieved with incomplete ablation conditioning regimens. BMT may provide a potential strategy to treat those autoimmune diseases for which today only symptomatic treatment is available.
AB - A variety of clinical and experimental reports have shown the interdependence between bone marrow and autoimmune diseases. Autoimmune diseases can be transferred as well as cured by hone marrow transplantation (BMT). The widespread application of this therapeutic approach is limited today by the morbidity and mortality associated with BMT, including failure of engraftment, graft-versus-host disease (GVHD) and the toxicity from lethal conditioning approaches. Mixed chimerism (with the advantage of superior immunocompetence of the host and a relative protection against GVHD) can be achieved with incomplete ablation conditioning regimens. BMT may provide a potential strategy to treat those autoimmune diseases for which today only symptomatic treatment is available.
KW - Autoimmunity
KW - Bone marrow transplantation
KW - Chimerism
KW - Conditioning
KW - Diabetes
KW - Facilitating cell
KW - NOD
UR - http://www.scopus.com/inward/record.url?scp=0030664607&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030664607&partnerID=8YFLogxK
M3 - Article
C2 - 9368338
AN - SCOPUS:0030664607
VL - 15
SP - 171
EP - 176
JO - Stem Cells
JF - Stem Cells
SN - 1066-5099
IS - SUPPL. 1
ER -