Bone marrow transplantation for therapy in autoimmune disease

B. G. Exner, J. H. Groninger, S. T. Ildstad, S. J. Sharkis, H. J. Kolb, E. D. Zanjani, P. J. Quesenberry, B. Torok-Storb

Research output: Contribution to journalArticle

Abstract

A variety of clinical and experimental reports have shown the interdependence between bone marrow and autoimmune diseases. Autoimmune diseases can be transferred as well as cured by hone marrow transplantation (BMT). The widespread application of this therapeutic approach is limited today by the morbidity and mortality associated with BMT, including failure of engraftment, graft-versus-host disease (GVHD) and the toxicity from lethal conditioning approaches. Mixed chimerism (with the advantage of superior immunocompetence of the host and a relative protection against GVHD) can be achieved with incomplete ablation conditioning regimens. BMT may provide a potential strategy to treat those autoimmune diseases for which today only symptomatic treatment is available.

Original languageEnglish (US)
Pages (from-to)171-176
Number of pages6
JournalStem Cells
Volume15
Issue numberSUPPL. 1
StatePublished - 1997
Externally publishedYes

Fingerprint

Bone Marrow Transplantation
Autoimmune Diseases
Transplantation
Bone Marrow
Graft vs Host Disease
Bone Marrow Diseases
Immunocompetence
Chimerism
Therapeutics
Morbidity
Mortality

Keywords

  • Autoimmunity
  • Bone marrow transplantation
  • Chimerism
  • Conditioning
  • Diabetes
  • Facilitating cell
  • NOD

ASJC Scopus subject areas

  • Cell Biology

Cite this

Exner, B. G., Groninger, J. H., Ildstad, S. T., Sharkis, S. J., Kolb, H. J., Zanjani, E. D., ... Torok-Storb, B. (1997). Bone marrow transplantation for therapy in autoimmune disease. Stem Cells, 15(SUPPL. 1), 171-176.

Bone marrow transplantation for therapy in autoimmune disease. / Exner, B. G.; Groninger, J. H.; Ildstad, S. T.; Sharkis, S. J.; Kolb, H. J.; Zanjani, E. D.; Quesenberry, P. J.; Torok-Storb, B.

In: Stem Cells, Vol. 15, No. SUPPL. 1, 1997, p. 171-176.

Research output: Contribution to journalArticle

Exner, BG, Groninger, JH, Ildstad, ST, Sharkis, SJ, Kolb, HJ, Zanjani, ED, Quesenberry, PJ & Torok-Storb, B 1997, 'Bone marrow transplantation for therapy in autoimmune disease', Stem Cells, vol. 15, no. SUPPL. 1, pp. 171-176.
Exner BG, Groninger JH, Ildstad ST, Sharkis SJ, Kolb HJ, Zanjani ED et al. Bone marrow transplantation for therapy in autoimmune disease. Stem Cells. 1997;15(SUPPL. 1):171-176.
Exner, B. G. ; Groninger, J. H. ; Ildstad, S. T. ; Sharkis, S. J. ; Kolb, H. J. ; Zanjani, E. D. ; Quesenberry, P. J. ; Torok-Storb, B. / Bone marrow transplantation for therapy in autoimmune disease. In: Stem Cells. 1997 ; Vol. 15, No. SUPPL. 1. pp. 171-176.
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