Bone marrow transplantation for therapy in autoimmune disease

B. G. Exner, J. H. Groninger, S. T. Ildstad, S. J. Sharkis, H. J. Kolb, E. D. Zanjani, P. J. Quesenberry, B. Torok-Storb

Research output: Contribution to journalArticlepeer-review

Abstract

A variety of clinical and experimental reports have shown the interdependence between bone marrow and autoimmune diseases. Autoimmune diseases can be transferred as well as cured by hone marrow transplantation (BMT). The widespread application of this therapeutic approach is limited today by the morbidity and mortality associated with BMT, including failure of engraftment, graft-versus-host disease (GVHD) and the toxicity from lethal conditioning approaches. Mixed chimerism (with the advantage of superior immunocompetence of the host and a relative protection against GVHD) can be achieved with incomplete ablation conditioning regimens. BMT may provide a potential strategy to treat those autoimmune diseases for which today only symptomatic treatment is available.

Original languageEnglish (US)
Pages (from-to)171-176
Number of pages6
JournalStem Cells
Volume15
Issue numberSUPPL. 1
StatePublished - 1997
Externally publishedYes

Keywords

  • Autoimmunity
  • Bone marrow transplantation
  • Chimerism
  • Conditioning
  • Diabetes
  • Facilitating cell
  • NOD

ASJC Scopus subject areas

  • Cell Biology

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