Bone marrow transplantation for therapy in autoimmune disease

B. G. Exner; J. H. Groninger; S. T. Ildstad; S. J. Sharkis; H. J. Kolb; E. D. Zanjani; P. J. Quesenberry; B. Torok-Storb

Bone marrow transplantation for therapy in autoimmune disease

B. G. Exner, J. H. Groninger, S. T. Ildstad, S. J. Sharkis, H. J. Kolb, E. D. Zanjani, P. J. Quesenberry, B. Torok-Storb

Research output: Contribution to journal › Article › peer-review

Abstract

A variety of clinical and experimental reports have shown the interdependence between bone marrow and autoimmune diseases. Autoimmune diseases can be transferred as well as cured by hone marrow transplantation (BMT). The widespread application of this therapeutic approach is limited today by the morbidity and mortality associated with BMT, including failure of engraftment, graft-versus-host disease (GVHD) and the toxicity from lethal conditioning approaches. Mixed chimerism (with the advantage of superior immunocompetence of the host and a relative protection against GVHD) can be achieved with incomplete ablation conditioning regimens. BMT may provide a potential strategy to treat those autoimmune diseases for which today only symptomatic treatment is available.

Original language	English (US)
Pages (from-to)	171-176
Number of pages	6
Journal	Stem Cells
Volume	15
Issue number	SUPPL. 1
State	Published - 1997
Externally published	Yes

Keywords

Autoimmunity
Bone marrow transplantation
Chimerism
Conditioning
Diabetes
Facilitating cell
NOD

ASJC Scopus subject areas

Cell Biology

Cite this

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AU - Exner, B. G.

AU - Groninger, J. H.

AU - Ildstad, S. T.

AU - Sharkis, S. J.

AU - Kolb, H. J.

AU - Zanjani, E. D.

AU - Quesenberry, P. J.

AU - Torok-Storb, B.

PY - 1997

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N2 - A variety of clinical and experimental reports have shown the interdependence between bone marrow and autoimmune diseases. Autoimmune diseases can be transferred as well as cured by hone marrow transplantation (BMT). The widespread application of this therapeutic approach is limited today by the morbidity and mortality associated with BMT, including failure of engraftment, graft-versus-host disease (GVHD) and the toxicity from lethal conditioning approaches. Mixed chimerism (with the advantage of superior immunocompetence of the host and a relative protection against GVHD) can be achieved with incomplete ablation conditioning regimens. BMT may provide a potential strategy to treat those autoimmune diseases for which today only symptomatic treatment is available.

AB - A variety of clinical and experimental reports have shown the interdependence between bone marrow and autoimmune diseases. Autoimmune diseases can be transferred as well as cured by hone marrow transplantation (BMT). The widespread application of this therapeutic approach is limited today by the morbidity and mortality associated with BMT, including failure of engraftment, graft-versus-host disease (GVHD) and the toxicity from lethal conditioning approaches. Mixed chimerism (with the advantage of superior immunocompetence of the host and a relative protection against GVHD) can be achieved with incomplete ablation conditioning regimens. BMT may provide a potential strategy to treat those autoimmune diseases for which today only symptomatic treatment is available.

KW - Autoimmunity

KW - Bone marrow transplantation

KW - Chimerism

KW - Conditioning

KW - Diabetes

KW - Facilitating cell

KW - NOD

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Bone marrow transplantation for therapy in autoimmune disease

Abstract

Keywords

ASJC Scopus subject areas

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