Bone marrow perfusion evaluated with gadolinium-enhanced dynamic fast MR imaging in a dog model

Maria Cova, Young S. Kang, Hiroshi Tsukamoto, Lynne C. Jones, Elliot McVeigh, Barbara L. Neff, Christian J. Herold, William W. Scott, David S. Hungerford, Elias A. Zerhouni

Research output: Contribution to journalArticlepeer-review


The authors studied, in a dog model, the feasibility of using gadoliniumenhanced dynamic magnetic resonance (MR) imaging to noninvasively monitor bone marrow perfusion of the proximal femur. With a gradient-recalled acquisition, sequential images of 10 hips in five healthy dogs were obtained for 14 minutes after an intravenous bolus injection of 0.2 mmol of gadopentetate dimeglumine per kilogram. The study was repeated after unilateral arterial embolization of major femoral vessels. Radiolabeled microspheres were injected before and after vessel occlusion. After unilateral embolization, statistically significant differences in enhancement were observed between embolized and control sides (eg, 31% vs 83% average peak enhancement in the femoral neck). There was a high correlation (r = .81 [average]) between the MR data and the microsphere blood flow measurements. The postembolization data indicate that contrastenhanced fast MR imaging may allow early detection of abnormal bone marrow flow. This technique may be valuable in evaluating patients at risk for avascular necrosis of the femoral head, especially in posttraumatic cases.

Original languageEnglish (US)
Pages (from-to)535-539
Number of pages5
Issue number2
StatePublished - May 1991


  • Blood, MR studies, 9*.1214
  • Blood, flow dynamics, 92.76
  • Bone marrow, MR studies, 443.1214
  • Femur, MR studies, 443.1214
  • Gadolinium
  • Magnetic resonance (MR), perfusion study, 443.1214
  • Magnetic resonance (MR), rapid imaging
  • Microspheres

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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