Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling

Research output: Contribution to journalArticle

Abstract

During bone resorption, abundant factors previously buried in the bone matrix are released into the bone marrow microenvironment, which results in recruitment and differentiation of bone marrow mesenchymal stem cells (MSCs) for subsequent bone formation, temporally and spatially coupling bone remodeling. Parathyroid hormone (PTH) orchestrates the signaling of many pathways that direct MSC fate. The spatiotemporal release and activation of matrix TGF-β during osteoclast bone resorption recruits MSCs to bone-resorptive sites. Dysregulation of TGF-β alters MSC fate, uncoupling bone remodeling and causing skeletal disorders. Modulation of TGF-β or PTH signaling may reestablish coupled bone remodeling and be a potential therapy.

Original languageEnglish (US)
Pages (from-to)466-472
Number of pages7
JournalJournal of Clinical Investigation
Volume124
Issue number2
DOIs
StatePublished - Feb 3 2014

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Bone Remodeling
Mesenchymal Stromal Cells
Bone Marrow
Bone Resorption
Parathyroid Hormone
Bone Matrix
Osteoclasts
Osteogenesis
Bone and Bones
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling. / Crane, Janet; Cao, Xu.

In: Journal of Clinical Investigation, Vol. 124, No. 2, 03.02.2014, p. 466-472.

Research output: Contribution to journalArticle

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