Bone loss in the HIV-infected patient

Evidence, clinical implications, and treatment strategies

Vanessa Walker Harris, Todd T Brown

Research output: Contribution to journalArticle

Abstract

Osteoporosis is common in human immunodeficiency virus (HIV)-infected persons. The etiology of osteoporosis in HIV-infected patients is likely multifactorial, involving traditional risk factors such as low body weight, hypogonadism, and smoking, as well as direct effects of chronic HIV infection and antiretroviral therapy. Emerging evidence suggests that the increasing prevalence of osteoporosis in HIV-infected persons translates into a higher risk of fracture, likely leading to excess morbidity and mortality as the HIV-infected population ages. This review addresses the epidemiology of osteoporosis, discusses the causes of low bone mineral density in HIV-infected persons, including the impact of specific antiretroviral therapies, and offers recommendations on screening and treating vitamin D deficiency and osteoporosis.

Original languageEnglish (US)
JournalJournal of Infectious Diseases
Volume205
Issue numberSUPPL. 3
DOIs
StatePublished - Jun 1 2012

Fingerprint

Osteoporosis
HIV
Bone and Bones
Therapeutics
Vitamin D Deficiency
Hypogonadism
Virus Diseases
Bone Density
Epidemiology
Smoking
Body Weight
Morbidity
Mortality
Population

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

Bone loss in the HIV-infected patient : Evidence, clinical implications, and treatment strategies. / Walker Harris, Vanessa; Brown, Todd T.

In: Journal of Infectious Diseases, Vol. 205, No. SUPPL. 3, 01.06.2012.

Research output: Contribution to journalArticle

@article{1e6224b7af384454a9ded7a06c406c0a,
title = "Bone loss in the HIV-infected patient: Evidence, clinical implications, and treatment strategies",
abstract = "Osteoporosis is common in human immunodeficiency virus (HIV)-infected persons. The etiology of osteoporosis in HIV-infected patients is likely multifactorial, involving traditional risk factors such as low body weight, hypogonadism, and smoking, as well as direct effects of chronic HIV infection and antiretroviral therapy. Emerging evidence suggests that the increasing prevalence of osteoporosis in HIV-infected persons translates into a higher risk of fracture, likely leading to excess morbidity and mortality as the HIV-infected population ages. This review addresses the epidemiology of osteoporosis, discusses the causes of low bone mineral density in HIV-infected persons, including the impact of specific antiretroviral therapies, and offers recommendations on screening and treating vitamin D deficiency and osteoporosis.",
author = "{Walker Harris}, Vanessa and Brown, {Todd T}",
year = "2012",
month = "6",
day = "1",
doi = "10.1093/infdis/jis199",
language = "English (US)",
volume = "205",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "SUPPL. 3",

}

TY - JOUR

T1 - Bone loss in the HIV-infected patient

T2 - Evidence, clinical implications, and treatment strategies

AU - Walker Harris, Vanessa

AU - Brown, Todd T

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Osteoporosis is common in human immunodeficiency virus (HIV)-infected persons. The etiology of osteoporosis in HIV-infected patients is likely multifactorial, involving traditional risk factors such as low body weight, hypogonadism, and smoking, as well as direct effects of chronic HIV infection and antiretroviral therapy. Emerging evidence suggests that the increasing prevalence of osteoporosis in HIV-infected persons translates into a higher risk of fracture, likely leading to excess morbidity and mortality as the HIV-infected population ages. This review addresses the epidemiology of osteoporosis, discusses the causes of low bone mineral density in HIV-infected persons, including the impact of specific antiretroviral therapies, and offers recommendations on screening and treating vitamin D deficiency and osteoporosis.

AB - Osteoporosis is common in human immunodeficiency virus (HIV)-infected persons. The etiology of osteoporosis in HIV-infected patients is likely multifactorial, involving traditional risk factors such as low body weight, hypogonadism, and smoking, as well as direct effects of chronic HIV infection and antiretroviral therapy. Emerging evidence suggests that the increasing prevalence of osteoporosis in HIV-infected persons translates into a higher risk of fracture, likely leading to excess morbidity and mortality as the HIV-infected population ages. This review addresses the epidemiology of osteoporosis, discusses the causes of low bone mineral density in HIV-infected persons, including the impact of specific antiretroviral therapies, and offers recommendations on screening and treating vitamin D deficiency and osteoporosis.

UR - http://www.scopus.com/inward/record.url?scp=84861063919&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861063919&partnerID=8YFLogxK

U2 - 10.1093/infdis/jis199

DO - 10.1093/infdis/jis199

M3 - Article

VL - 205

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - SUPPL. 3

ER -