Bone health in facioscapulohumeral muscular dystrophy: A cross-sectional study

Hema Chagarlamudi, Alastair Corbett, Marion Stoll, Genila Bibat, Carla Grosmann, Carly Matichak Stock, Nikia Stinson, Jay Shapiro, Kathryn R. Wagner

Research output: Research - peer-reviewArticle

Abstract

Introduction: Herein we provide a comprehensive overview of bone health in facioscapulohumeral muscular dystrophy (FSHD). Methods: Ninety-four adult individuals with FSHD type 1 from 2 sites were included in this cross-sectional study. Clinical characteristics and determinants of bone health were examined. Relationships between bone mineral density (BMD), strength, and function were explored. Results: Nearly a third of subjects were deficient in vitamin D3. Mean whole-body BMD z-score was −0.7; 11% of subjects had greater than age-related reductions in whole-body BMD (z-score < −2.0). Whole-body and regional BMDs were associated with strength and function. Thirty-six percent had a history of fractures. Likelihood of fractures was reduced for those with normal whole-body BMD (odds ratio = 0.25, 95% confidence interval 0.04–0.78). Discussion: A diagnosis of FSHD is not necessarily predictive of reduced BMD or increased fracture rate. Given the considerable variability of bone health in the FSHD population, strength and function can serve as predictors of BMD. Muscle Nerve 56: 1108–1113, 2017.

LanguageEnglish (US)
Pages1108-1113
Number of pages6
JournalMuscle and Nerve
Volume56
Issue number6
DOIs
StatePublished - Dec 1 2017
Externally publishedYes

Fingerprint

Facioscapulohumeral Muscular Dystrophy
Bone Density
Cross-Sectional Studies
Bone and Bones
Health
Cholecalciferol
Odds Ratio
Confidence Intervals
Muscles
Population

Keywords

  • bone density
  • bone health
  • bone mineral density
  • facioscapulohumeral muscular dystrophy
  • muscular dystrophy

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

Chagarlamudi, H., Corbett, A., Stoll, M., Bibat, G., Grosmann, C., Matichak Stock, C., ... Wagner, K. R. (2017). Bone health in facioscapulohumeral muscular dystrophy: A cross-sectional study. Muscle and Nerve, 56(6), 1108-1113. DOI: 10.1002/mus.25619

Bone health in facioscapulohumeral muscular dystrophy : A cross-sectional study. / Chagarlamudi, Hema; Corbett, Alastair; Stoll, Marion; Bibat, Genila; Grosmann, Carla; Matichak Stock, Carly; Stinson, Nikia; Shapiro, Jay; Wagner, Kathryn R.

In: Muscle and Nerve, Vol. 56, No. 6, 01.12.2017, p. 1108-1113.

Research output: Research - peer-reviewArticle

Chagarlamudi, H, Corbett, A, Stoll, M, Bibat, G, Grosmann, C, Matichak Stock, C, Stinson, N, Shapiro, J & Wagner, KR 2017, 'Bone health in facioscapulohumeral muscular dystrophy: A cross-sectional study' Muscle and Nerve, vol 56, no. 6, pp. 1108-1113. DOI: 10.1002/mus.25619
Chagarlamudi H, Corbett A, Stoll M, Bibat G, Grosmann C, Matichak Stock C et al. Bone health in facioscapulohumeral muscular dystrophy: A cross-sectional study. Muscle and Nerve. 2017 Dec 1;56(6):1108-1113. Available from, DOI: 10.1002/mus.25619
Chagarlamudi, Hema ; Corbett, Alastair ; Stoll, Marion ; Bibat, Genila ; Grosmann, Carla ; Matichak Stock, Carly ; Stinson, Nikia ; Shapiro, Jay ; Wagner, Kathryn R./ Bone health in facioscapulohumeral muscular dystrophy : A cross-sectional study. In: Muscle and Nerve. 2017 ; Vol. 56, No. 6. pp. 1108-1113
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