TY - JOUR
T1 - Bone growth patterns in Chinese children and adolescents
T2 - A 6-year follow-up study provides evidence for sexual dimorphism and tracking
AU - Ouyang, Fengxiu
AU - Wang, Binyan
AU - Arguelles, Lester M.
AU - Xu, Xiping
AU - Yang, Jianhua
AU - Li, Zhiping
AU - Wang, Liuliu
AU - Liu, Xue
AU - Tang, Genfu
AU - Xing, Houxun
AU - Langman, Craig
AU - Wang, Xiaobin
N1 - Funding Information:
Source(s) of support: This study is supported in part by grant R01 HD049059, R01 HL0864619 and R01 AR045651 from the National Institute of Health and by the Food Allergy Project. F.Ouyang.B.Wang.X.Wang Mary Ann and J. Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children’s Memorial Hospital and Children’s Memorial Research Center, Chicago, IL, USA
PY - 2007/12
Y1 - 2007/12
N2 - Summary: We prospectively examined bone growth patterns in 894 children aged 6-17 years at the baseline visit, with a 6-year follow-up. Results show bone "tracking" over a six-year interval and sexual dimorphism of bone attained levels and timing of peak bone growth. Our findings underscore childhood and adolescence as critical periods for building bone and developing gender differences. Introduction: Bone growth patterns were prospectively examined in 894 Chinese children (496 males), aged 6-17 yrs, from a population-based twin cohort. Whole-body bone area (BA), bone mineral content (BMC), and bone mineral density (BMD) were measured by DEXA at baseline and a 6-yr follow-up. Methods: Graphic smoothing plots and generalized estimating equations were used to model bone attained levels, growth, and "tracking". Results: Attained levels of BMC and BA increased curvilinearly with age. Male attained levels were higher than females after age ∼15 yr, but BMD was lower between 13-17 yrs (Tanner stage I to IV). In both genders, peak BMC and BMD growth lagged ∼2 yrs behind peak BA growth, which lagged 2 yrs behind peak height growth. Peak bone growth occurred 1-3 yrs later in males. Over the 6-yr follow-up, all bone measurements "tracked", but "shifting" across ranks also occurred, and baseline tertile ranking influenced bone growth. Females with early menarche had higher attained levels than females with late menarche at age 12-13 yrs. Conclusion: Our findings confirm and expand previous studies on peak bone growth conducted in Caucasian cohorts, particularly sexually dimorphic and maturational effects. The significant "tracking" of bone measurements in this 6-yr follow-up study underscores the importance that osteoporosis prevention should begin in childhood and adolescence.
AB - Summary: We prospectively examined bone growth patterns in 894 children aged 6-17 years at the baseline visit, with a 6-year follow-up. Results show bone "tracking" over a six-year interval and sexual dimorphism of bone attained levels and timing of peak bone growth. Our findings underscore childhood and adolescence as critical periods for building bone and developing gender differences. Introduction: Bone growth patterns were prospectively examined in 894 Chinese children (496 males), aged 6-17 yrs, from a population-based twin cohort. Whole-body bone area (BA), bone mineral content (BMC), and bone mineral density (BMD) were measured by DEXA at baseline and a 6-yr follow-up. Methods: Graphic smoothing plots and generalized estimating equations were used to model bone attained levels, growth, and "tracking". Results: Attained levels of BMC and BA increased curvilinearly with age. Male attained levels were higher than females after age ∼15 yr, but BMD was lower between 13-17 yrs (Tanner stage I to IV). In both genders, peak BMC and BMD growth lagged ∼2 yrs behind peak BA growth, which lagged 2 yrs behind peak height growth. Peak bone growth occurred 1-3 yrs later in males. Over the 6-yr follow-up, all bone measurements "tracked", but "shifting" across ranks also occurred, and baseline tertile ranking influenced bone growth. Females with early menarche had higher attained levels than females with late menarche at age 12-13 yrs. Conclusion: Our findings confirm and expand previous studies on peak bone growth conducted in Caucasian cohorts, particularly sexually dimorphic and maturational effects. The significant "tracking" of bone measurements in this 6-yr follow-up study underscores the importance that osteoporosis prevention should begin in childhood and adolescence.
KW - Bone area
KW - Bone growth
KW - Bone mineral content
KW - Bone mineral density
KW - Children and adolescents
KW - Longitudinal study
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U2 - 10.1007/s11657-007-0015-8
DO - 10.1007/s11657-007-0015-8
M3 - Article
AN - SCOPUS:37449000062
SN - 1862-3522
VL - 2
SP - 29
EP - 43
JO - Archives of Osteoporosis
JF - Archives of Osteoporosis
IS - 1-2
ER -