Abstract
Mesenchymal progenitor cells are broadly distributed across perivascular niches—an observation conserved between species. One common histologic zone with a high frequency of mesenchymal progenitor cells within mammalian tissues is the tunica adventitia, the outer layer of blood vessel walls populated by cells with a fibroblastic morphology. The diversity and functions of (re)generative cells present in this outermost perivascular niche are under intense investigation; we have reviewed herein our current knowledge of adventitial cell potential with a somewhat narrow focus on bone formation. Antigens of interest to functionally segregate adventicytes are discussed, including CD10, CD107a, aldehyde dehydrogenase isoforms, and CD140a, among others. Purified adventicytes (such as CD10+, CD107alow, and CD140a+ cells) have stronger osteogenic potential and promote bone formation in vivo. Recent bone tissue engineering applications of adventitial cells are also presented. A better understanding of perivascular progenitor cell subsets may represent a beneficial advance for future efforts in tissue repair and bioengineering.
Original language | English (US) |
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Pages (from-to) | 1427-1434 |
Number of pages | 8 |
Journal | Stem Cells |
Volume | 39 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2021 |
Keywords
- ALDH
- CD10
- CD107a
- CD140a
- LAMP1
- adipogenesis
- adipose stem cell
- exocytosis
- mesenchymal stem cell
- mesenchymal stromal cell
- osteogenesis
- perivascular stem cell
- tunica adventitia
ASJC Scopus subject areas
- General Medicine