Bombesin affects feeding independent of a gastric mechanism or site of action

A. M. Hostetler, P. R. McHugh, T. H. Moran

Research output: Contribution to journalArticlepeer-review

Abstract

Peripherally administered bombesin has been demonstrated to inhibit food intake in a variety of species. Although the behavioral actions of bombesin are well characterized, neither the site of action nor mechanism through which bombesin affects feeding has been demonstrated. To test the hypothesis that bombesin's feeding effects are through a gastric inhibitory mechanism or a gastric site of action we examined the potential relationship between the inhibition of gastric emptying and the inhibition of intake produced across a dose range of bombesin and compared the relative potency of bombesin analogues for inhibiting feeding with their affinity for gastric bombesin receptors. Comparisons of the inhibitions of gastric emptying and feeding produced by 2, 4, 8, or 16 μg/kg of bombesin revealed no relationship, and, in fact, no gastric inhibitory action was evident. The feeding inhibitory actions of dose ranges (100 pmol-100 nmol) of litorin, ranatensin, acetylated gastrin-releasing peptide-(20-27) [AcGRP-(20-27)] and bombesin-(8-14) fragment were assessed and compared with bombesin. These compounds inhibited feeding with a relative potency of bombesin > AcGRP-(20-27) > ranatensin > litorin > bombesin-(8-14). This rank order of potency differed from the relative affinity of these compounds for gastric bombesin receptors for which all of these compounds except bombesin-(8-14) have a greater affinity than does bombesin. The results of these two experiments suggest that bombesin's satiety actions are not mediated by a gastric inhibitory mechanism or through a gastric site of action

Original languageEnglish (US)
Pages (from-to)26/5
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume257
Issue number5
StatePublished - 1989

Keywords

  • gastrin-releasing peptide
  • litorin
  • peptides
  • ranatensin
  • receptors

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Bombesin affects feeding independent of a gastric mechanism or site of action'. Together they form a unique fingerprint.

Cite this