Body weight patterns from 20 to 49 years of age and subsequent risk for diabetes mellitus: The Johns Hopkins precursors study

Frederick L. Brancati, Nae Yuh Wang, Lucy A. Mead, Kung Yee Liang, Michael John Klag

Research output: Contribution to journalArticle

Abstract

Background: Obesity in middle age is a well-known risk factor for the development of type 2 diabetes mellitus. However, the importance of weight and weight gain at younger ages is less certain. Objective: To determine the relationship of body weight patterns from 20 to 49 years of age with the subsequent risk for type 2 diabetes mellitus. Setting: An ongoing longitudinal study of former medical students. Participants: Nine hundred sixteen white men without diabetes at 50 years of age. Measurements: Weight and height measured in medical school, then assessed by mailed questionnaire to 49 years of age. Main Outcome: Incident type 2 diabetes mellitus based on physician self-report. Results: During 14 255 person-years of follow-up, there were 35 incident cases of type 2 diabetes mellitus (2.5 per 1000 person-years). After simultaneous adjustment for age, physical activity, lifetime maternal history of diabetes, and smoking, body mass indexes (BMIs; calculated as weight in kilograms divided by the square of height in meters) at 25, 35, and 45 years of age were all strongly associated with diabetes risk (relative risks for overweight [BMI ≥25.0] vs not overweight, >3.0; all Ps

Original languageEnglish (US)
Pages (from-to)957-963
Number of pages7
JournalArchives of Internal Medicine
Volume159
Issue number9
DOIs
StatePublished - May 10 1999

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Type 2 Diabetes Mellitus
Diabetes Mellitus
Body Weight
Weights and Measures
Medical Schools
Medical Students
Self Report
Weight Gain
Longitudinal Studies
Body Mass Index
Obesity
Smoking
Mothers
Exercise
Physicians

ASJC Scopus subject areas

  • Internal Medicine

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Body weight patterns from 20 to 49 years of age and subsequent risk for diabetes mellitus : The Johns Hopkins precursors study. / Brancati, Frederick L.; Wang, Nae Yuh; Mead, Lucy A.; Liang, Kung Yee; Klag, Michael John.

In: Archives of Internal Medicine, Vol. 159, No. 9, 10.05.1999, p. 957-963.

Research output: Contribution to journalArticle

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