Body temperature and mortality in patients with acute respiratory distress syndrome

Hildy M. Schell-Chaple, Kathleen A. Puntillo, Michael A. Matthay, Kathleen D. Liu, Herbert P. Wiedemann, Alejandro C. Arroliga, Charles J. Fisher, John J. Komara, Patricia Periz-Trepichio, Polly E. Parsons, Carolyn Welsh, William J. Fulkerson, Neil MacIntyre, Lee Mallatratt, Mark Sebastian, John Davies, Elizabeth Van Dyne, Joseph Govert, Jonathan Sevransky, Stacey MurrayRoy G Brower, David Thompson, Henry Eric Fessler, Alan H. Morris, Terry Clemmer, Robin Davis, James Orme, Lindell Weaver, Colin Grissom, Frank Thomas, Martin Gleich, Charles Lawton, Janice D'Hulst, Joel R. Peerless, Carolyn Smith, Richard Kallet, John M. Luce, Jonathan Gottlieb, Pauline Park, Aimee Girod, Lisa Yannarell, San Francisco, Mark D. Eisner, Brian Daniel, Edward Abraham, Fran Piedalue, Rebecca Jagusch, Paul Miller, Robert McIntyre, Kelley E. Greene, Henry J. Silverman, Carl Shanholtz, Wanda Corral, Galen B. Toews, Deborah Arnoldi, Robert H. Bartlett, Ron Dechert, Charles Watts, Paul N. Lanken, Harry Anderson, Barbara Finkel, C. William Hanson, Richard Barton, Mary Mone, Leonard D. Hudson, Greg Carter, Claudette Lee Cooper, Annemieke Hiemstra, Ronald V. Maier, Kenneth P. Steinberg, Tracy Hill, Phil Thaut, Arthur P. Wheeler, Gordon Bernard, Brian Christman, Susan Bozeman, Linda Collins, Teresa Swope, Lorraine B. Ware, David A. Schoenfeld, B. Taylor Thompson, Marek Ancukiewicz, Douglas Hayden, Francine Molay, Nancy Ringwood, Gail Wenzlow, Ali S. Kazeroonin, Dorothy B. Gail, Andrea Harabin, Pamela Lew, Myron Waclawiw, Gordon R. Bernard, Roger G. Spragg, James Boyett, Jason Kelley, Kenneth Leeper, Marion Gray Secundy, Arthur Slutsky, Joe G N Garcia, Scott S. Emerson, Susan K. Pingleton, Michael D. Shasby, William J. Sibbald

Research output: Contribution to journalArticle

Abstract

Background: Little is known about the relationship between body temperature and outcomes in patients with acute respiratory distress syndrome (ARDS). A better understanding of this relationship may provide evidence for fever suppression or warming interventions, which are commonly applied in practice. Objective: To examine the relationship between body temperature and mortality in patients with ARDS. Methods: Secondary analysis of body temperature and mortality using data from the ARDS Network Fluid and Catheter Treatment Trial (n = 969). Body temperature at baseline and on study day 2, primary cause of ARDS, severity of illness, and 90-day mortality were analyzed by using multiple logistic regression. Results: Mean baseline temperature was 37.5°C (SD, 1.1°C; range, 27.2°C-40.7°C). At baseline, fever (≥ 38.3°C) was present in 23% and hypothermia (<36°C) in 5% of the patients. Body temperature was a significant predictor of 90-day mortality after primary cause of ARDS and score on the Acute Physiology and Chronic Health Evaluation III were adjusted for. Higher temperature was associated with decreased mortality: for every 1°C increase in baseline temperature, the odds of death decreased by 15% (odds ratio, 0.85; 95% CI, 0.73-0.98, P = .03). When patients were divided into 5 temperature groups, mortality was lower with higher temperature (P for trend = .02). Conclusions: Early in ARDS, fever is associated with improved survival rates. Fever in the acute phase response to lung injury and its relationship to recovery may be an important factor in determining patients' outcome and warrants further study.

Original languageEnglish (US)
Pages (from-to)15-23
Number of pages9
JournalAmerican Journal of Critical Care
Volume24
Issue number1
DOIs
StatePublished - 2015

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Adult Respiratory Distress Syndrome
Body Temperature
Mortality
Fever
Temperature
Sick Leave
Acute-Phase Reaction
APACHE
Lung Injury
Hypothermia
Catheters
Survival Rate
Logistic Models
Odds Ratio

ASJC Scopus subject areas

  • Critical Care

Cite this

Schell-Chaple, H. M., Puntillo, K. A., Matthay, M. A., Liu, K. D., Wiedemann, H. P., Arroliga, A. C., ... Sibbald, W. J. (2015). Body temperature and mortality in patients with acute respiratory distress syndrome. American Journal of Critical Care, 24(1), 15-23. https://doi.org/10.4037/ajcc2015320

Body temperature and mortality in patients with acute respiratory distress syndrome. / Schell-Chaple, Hildy M.; Puntillo, Kathleen A.; Matthay, Michael A.; Liu, Kathleen D.; Wiedemann, Herbert P.; Arroliga, Alejandro C.; Fisher, Charles J.; Komara, John J.; Periz-Trepichio, Patricia; Parsons, Polly E.; Welsh, Carolyn; Fulkerson, William J.; MacIntyre, Neil; Mallatratt, Lee; Sebastian, Mark; Davies, John; Dyne, Elizabeth Van; Govert, Joseph; Sevransky, Jonathan; Murray, Stacey; Brower, Roy G; Thompson, David; Fessler, Henry Eric; Morris, Alan H.; Clemmer, Terry; Davis, Robin; Orme, James; Weaver, Lindell; Grissom, Colin; Thomas, Frank; Gleich, Martin; Lawton, Charles; D'Hulst, Janice; Peerless, Joel R.; Smith, Carolyn; Kallet, Richard; Luce, John M.; Gottlieb, Jonathan; Park, Pauline; Girod, Aimee; Yannarell, Lisa; Francisco, San; Eisner, Mark D.; Daniel, Brian; Abraham, Edward; Piedalue, Fran; Jagusch, Rebecca; Miller, Paul; McIntyre, Robert; Greene, Kelley E.; Silverman, Henry J.; Shanholtz, Carl; Corral, Wanda; Toews, Galen B.; Arnoldi, Deborah; Bartlett, Robert H.; Dechert, Ron; Watts, Charles; Lanken, Paul N.; Anderson, Harry; Finkel, Barbara; Hanson, C. William; Barton, Richard; Mone, Mary; Hudson, Leonard D.; Carter, Greg; Cooper, Claudette Lee; Hiemstra, Annemieke; Maier, Ronald V.; Steinberg, Kenneth P.; Hill, Tracy; Thaut, Phil; Wheeler, Arthur P.; Bernard, Gordon; Christman, Brian; Bozeman, Susan; Collins, Linda; Swope, Teresa; Ware, Lorraine B.; Schoenfeld, David A.; Thompson, B. Taylor; Ancukiewicz, Marek; Hayden, Douglas; Molay, Francine; Ringwood, Nancy; Wenzlow, Gail; Kazeroonin, Ali S.; Gail, Dorothy B.; Harabin, Andrea; Lew, Pamela; Waclawiw, Myron; Bernard, Gordon R.; Spragg, Roger G.; Boyett, James; Kelley, Jason; Leeper, Kenneth; Secundy, Marion Gray; Slutsky, Arthur; Garcia, Joe G N; Emerson, Scott S.; Pingleton, Susan K.; Shasby, Michael D.; Sibbald, William J.

In: American Journal of Critical Care, Vol. 24, No. 1, 2015, p. 15-23.

Research output: Contribution to journalArticle

Schell-Chaple, HM, Puntillo, KA, Matthay, MA, Liu, KD, Wiedemann, HP, Arroliga, AC, Fisher, CJ, Komara, JJ, Periz-Trepichio, P, Parsons, PE, Welsh, C, Fulkerson, WJ, MacIntyre, N, Mallatratt, L, Sebastian, M, Davies, J, Dyne, EV, Govert, J, Sevransky, J, Murray, S, Brower, RG, Thompson, D, Fessler, HE, Morris, AH, Clemmer, T, Davis, R, Orme, J, Weaver, L, Grissom, C, Thomas, F, Gleich, M, Lawton, C, D'Hulst, J, Peerless, JR, Smith, C, Kallet, R, Luce, JM, Gottlieb, J, Park, P, Girod, A, Yannarell, L, Francisco, S, Eisner, MD, Daniel, B, Abraham, E, Piedalue, F, Jagusch, R, Miller, P, McIntyre, R, Greene, KE, Silverman, HJ, Shanholtz, C, Corral, W, Toews, GB, Arnoldi, D, Bartlett, RH, Dechert, R, Watts, C, Lanken, PN, Anderson, H, Finkel, B, Hanson, CW, Barton, R, Mone, M, Hudson, LD, Carter, G, Cooper, CL, Hiemstra, A, Maier, RV, Steinberg, KP, Hill, T, Thaut, P, Wheeler, AP, Bernard, G, Christman, B, Bozeman, S, Collins, L, Swope, T, Ware, LB, Schoenfeld, DA, Thompson, BT, Ancukiewicz, M, Hayden, D, Molay, F, Ringwood, N, Wenzlow, G, Kazeroonin, AS, Gail, DB, Harabin, A, Lew, P, Waclawiw, M, Bernard, GR, Spragg, RG, Boyett, J, Kelley, J, Leeper, K, Secundy, MG, Slutsky, A, Garcia, JGN, Emerson, SS, Pingleton, SK, Shasby, MD & Sibbald, WJ 2015, 'Body temperature and mortality in patients with acute respiratory distress syndrome', American Journal of Critical Care, vol. 24, no. 1, pp. 15-23. https://doi.org/10.4037/ajcc2015320
Schell-Chaple HM, Puntillo KA, Matthay MA, Liu KD, Wiedemann HP, Arroliga AC et al. Body temperature and mortality in patients with acute respiratory distress syndrome. American Journal of Critical Care. 2015;24(1):15-23. https://doi.org/10.4037/ajcc2015320
Schell-Chaple, Hildy M. ; Puntillo, Kathleen A. ; Matthay, Michael A. ; Liu, Kathleen D. ; Wiedemann, Herbert P. ; Arroliga, Alejandro C. ; Fisher, Charles J. ; Komara, John J. ; Periz-Trepichio, Patricia ; Parsons, Polly E. ; Welsh, Carolyn ; Fulkerson, William J. ; MacIntyre, Neil ; Mallatratt, Lee ; Sebastian, Mark ; Davies, John ; Dyne, Elizabeth Van ; Govert, Joseph ; Sevransky, Jonathan ; Murray, Stacey ; Brower, Roy G ; Thompson, David ; Fessler, Henry Eric ; Morris, Alan H. ; Clemmer, Terry ; Davis, Robin ; Orme, James ; Weaver, Lindell ; Grissom, Colin ; Thomas, Frank ; Gleich, Martin ; Lawton, Charles ; D'Hulst, Janice ; Peerless, Joel R. ; Smith, Carolyn ; Kallet, Richard ; Luce, John M. ; Gottlieb, Jonathan ; Park, Pauline ; Girod, Aimee ; Yannarell, Lisa ; Francisco, San ; Eisner, Mark D. ; Daniel, Brian ; Abraham, Edward ; Piedalue, Fran ; Jagusch, Rebecca ; Miller, Paul ; McIntyre, Robert ; Greene, Kelley E. ; Silverman, Henry J. ; Shanholtz, Carl ; Corral, Wanda ; Toews, Galen B. ; Arnoldi, Deborah ; Bartlett, Robert H. ; Dechert, Ron ; Watts, Charles ; Lanken, Paul N. ; Anderson, Harry ; Finkel, Barbara ; Hanson, C. William ; Barton, Richard ; Mone, Mary ; Hudson, Leonard D. ; Carter, Greg ; Cooper, Claudette Lee ; Hiemstra, Annemieke ; Maier, Ronald V. ; Steinberg, Kenneth P. ; Hill, Tracy ; Thaut, Phil ; Wheeler, Arthur P. ; Bernard, Gordon ; Christman, Brian ; Bozeman, Susan ; Collins, Linda ; Swope, Teresa ; Ware, Lorraine B. ; Schoenfeld, David A. ; Thompson, B. Taylor ; Ancukiewicz, Marek ; Hayden, Douglas ; Molay, Francine ; Ringwood, Nancy ; Wenzlow, Gail ; Kazeroonin, Ali S. ; Gail, Dorothy B. ; Harabin, Andrea ; Lew, Pamela ; Waclawiw, Myron ; Bernard, Gordon R. ; Spragg, Roger G. ; Boyett, James ; Kelley, Jason ; Leeper, Kenneth ; Secundy, Marion Gray ; Slutsky, Arthur ; Garcia, Joe G N ; Emerson, Scott S. ; Pingleton, Susan K. ; Shasby, Michael D. ; Sibbald, William J. / Body temperature and mortality in patients with acute respiratory distress syndrome. In: American Journal of Critical Care. 2015 ; Vol. 24, No. 1. pp. 15-23.
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title = "Body temperature and mortality in patients with acute respiratory distress syndrome",
abstract = "Background: Little is known about the relationship between body temperature and outcomes in patients with acute respiratory distress syndrome (ARDS). A better understanding of this relationship may provide evidence for fever suppression or warming interventions, which are commonly applied in practice. Objective: To examine the relationship between body temperature and mortality in patients with ARDS. Methods: Secondary analysis of body temperature and mortality using data from the ARDS Network Fluid and Catheter Treatment Trial (n = 969). Body temperature at baseline and on study day 2, primary cause of ARDS, severity of illness, and 90-day mortality were analyzed by using multiple logistic regression. Results: Mean baseline temperature was 37.5°C (SD, 1.1°C; range, 27.2°C-40.7°C). At baseline, fever (≥ 38.3°C) was present in 23{\%} and hypothermia (<36°C) in 5{\%} of the patients. Body temperature was a significant predictor of 90-day mortality after primary cause of ARDS and score on the Acute Physiology and Chronic Health Evaluation III were adjusted for. Higher temperature was associated with decreased mortality: for every 1°C increase in baseline temperature, the odds of death decreased by 15{\%} (odds ratio, 0.85; 95{\%} CI, 0.73-0.98, P = .03). When patients were divided into 5 temperature groups, mortality was lower with higher temperature (P for trend = .02). Conclusions: Early in ARDS, fever is associated with improved survival rates. Fever in the acute phase response to lung injury and its relationship to recovery may be an important factor in determining patients' outcome and warrants further study.",
author = "Schell-Chaple, {Hildy M.} and Puntillo, {Kathleen A.} and Matthay, {Michael A.} and Liu, {Kathleen D.} and Wiedemann, {Herbert P.} and Arroliga, {Alejandro C.} and Fisher, {Charles J.} and Komara, {John J.} and Patricia Periz-Trepichio and Parsons, {Polly E.} and Carolyn Welsh and Fulkerson, {William J.} and Neil MacIntyre and Lee Mallatratt and Mark Sebastian and John Davies and Dyne, {Elizabeth Van} and Joseph Govert and Jonathan Sevransky and Stacey Murray and Brower, {Roy G} and David Thompson and Fessler, {Henry Eric} and Morris, {Alan H.} and Terry Clemmer and Robin Davis and James Orme and Lindell Weaver and Colin Grissom and Frank Thomas and Martin Gleich and Charles Lawton and Janice D'Hulst and Peerless, {Joel R.} and Carolyn Smith and Richard Kallet and Luce, {John M.} and Jonathan Gottlieb and Pauline Park and Aimee Girod and Lisa Yannarell and San Francisco and Eisner, {Mark D.} and Brian Daniel and Edward Abraham and Fran Piedalue and Rebecca Jagusch and Paul Miller and Robert McIntyre and Greene, {Kelley E.} and Silverman, {Henry J.} and Carl Shanholtz and Wanda Corral and Toews, {Galen B.} and Deborah Arnoldi and Bartlett, {Robert H.} and Ron Dechert and Charles Watts and Lanken, {Paul N.} and Harry Anderson and Barbara Finkel and Hanson, {C. William} and Richard Barton and Mary Mone and Hudson, {Leonard D.} and Greg Carter and Cooper, {Claudette Lee} and Annemieke Hiemstra and Maier, {Ronald V.} and Steinberg, {Kenneth P.} and Tracy Hill and Phil Thaut and Wheeler, {Arthur P.} and Gordon Bernard and Brian Christman and Susan Bozeman and Linda Collins and Teresa Swope and Ware, {Lorraine B.} and Schoenfeld, {David A.} and Thompson, {B. Taylor} and Marek Ancukiewicz and Douglas Hayden and Francine Molay and Nancy Ringwood and Gail Wenzlow and Kazeroonin, {Ali S.} and Gail, {Dorothy B.} and Andrea Harabin and Pamela Lew and Myron Waclawiw and Bernard, {Gordon R.} and Spragg, {Roger G.} and James Boyett and Jason Kelley and Kenneth Leeper and Secundy, {Marion Gray} and Arthur Slutsky and Garcia, {Joe G N} and Emerson, {Scott S.} and Pingleton, {Susan K.} and Shasby, {Michael D.} and Sibbald, {William J.}",
year = "2015",
doi = "10.4037/ajcc2015320",
language = "English (US)",
volume = "24",
pages = "15--23",
journal = "American Journal of Critical Care",
issn = "1062-3264",
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TY - JOUR

T1 - Body temperature and mortality in patients with acute respiratory distress syndrome

AU - Schell-Chaple, Hildy M.

AU - Puntillo, Kathleen A.

AU - Matthay, Michael A.

AU - Liu, Kathleen D.

AU - Wiedemann, Herbert P.

AU - Arroliga, Alejandro C.

AU - Fisher, Charles J.

AU - Komara, John J.

AU - Periz-Trepichio, Patricia

AU - Parsons, Polly E.

AU - Welsh, Carolyn

AU - Fulkerson, William J.

AU - MacIntyre, Neil

AU - Mallatratt, Lee

AU - Sebastian, Mark

AU - Davies, John

AU - Dyne, Elizabeth Van

AU - Govert, Joseph

AU - Sevransky, Jonathan

AU - Murray, Stacey

AU - Brower, Roy G

AU - Thompson, David

AU - Fessler, Henry Eric

AU - Morris, Alan H.

AU - Clemmer, Terry

AU - Davis, Robin

AU - Orme, James

AU - Weaver, Lindell

AU - Grissom, Colin

AU - Thomas, Frank

AU - Gleich, Martin

AU - Lawton, Charles

AU - D'Hulst, Janice

AU - Peerless, Joel R.

AU - Smith, Carolyn

AU - Kallet, Richard

AU - Luce, John M.

AU - Gottlieb, Jonathan

AU - Park, Pauline

AU - Girod, Aimee

AU - Yannarell, Lisa

AU - Francisco, San

AU - Eisner, Mark D.

AU - Daniel, Brian

AU - Abraham, Edward

AU - Piedalue, Fran

AU - Jagusch, Rebecca

AU - Miller, Paul

AU - McIntyre, Robert

AU - Greene, Kelley E.

AU - Silverman, Henry J.

AU - Shanholtz, Carl

AU - Corral, Wanda

AU - Toews, Galen B.

AU - Arnoldi, Deborah

AU - Bartlett, Robert H.

AU - Dechert, Ron

AU - Watts, Charles

AU - Lanken, Paul N.

AU - Anderson, Harry

AU - Finkel, Barbara

AU - Hanson, C. William

AU - Barton, Richard

AU - Mone, Mary

AU - Hudson, Leonard D.

AU - Carter, Greg

AU - Cooper, Claudette Lee

AU - Hiemstra, Annemieke

AU - Maier, Ronald V.

AU - Steinberg, Kenneth P.

AU - Hill, Tracy

AU - Thaut, Phil

AU - Wheeler, Arthur P.

AU - Bernard, Gordon

AU - Christman, Brian

AU - Bozeman, Susan

AU - Collins, Linda

AU - Swope, Teresa

AU - Ware, Lorraine B.

AU - Schoenfeld, David A.

AU - Thompson, B. Taylor

AU - Ancukiewicz, Marek

AU - Hayden, Douglas

AU - Molay, Francine

AU - Ringwood, Nancy

AU - Wenzlow, Gail

AU - Kazeroonin, Ali S.

AU - Gail, Dorothy B.

AU - Harabin, Andrea

AU - Lew, Pamela

AU - Waclawiw, Myron

AU - Bernard, Gordon R.

AU - Spragg, Roger G.

AU - Boyett, James

AU - Kelley, Jason

AU - Leeper, Kenneth

AU - Secundy, Marion Gray

AU - Slutsky, Arthur

AU - Garcia, Joe G N

AU - Emerson, Scott S.

AU - Pingleton, Susan K.

AU - Shasby, Michael D.

AU - Sibbald, William J.

PY - 2015

Y1 - 2015

N2 - Background: Little is known about the relationship between body temperature and outcomes in patients with acute respiratory distress syndrome (ARDS). A better understanding of this relationship may provide evidence for fever suppression or warming interventions, which are commonly applied in practice. Objective: To examine the relationship between body temperature and mortality in patients with ARDS. Methods: Secondary analysis of body temperature and mortality using data from the ARDS Network Fluid and Catheter Treatment Trial (n = 969). Body temperature at baseline and on study day 2, primary cause of ARDS, severity of illness, and 90-day mortality were analyzed by using multiple logistic regression. Results: Mean baseline temperature was 37.5°C (SD, 1.1°C; range, 27.2°C-40.7°C). At baseline, fever (≥ 38.3°C) was present in 23% and hypothermia (<36°C) in 5% of the patients. Body temperature was a significant predictor of 90-day mortality after primary cause of ARDS and score on the Acute Physiology and Chronic Health Evaluation III were adjusted for. Higher temperature was associated with decreased mortality: for every 1°C increase in baseline temperature, the odds of death decreased by 15% (odds ratio, 0.85; 95% CI, 0.73-0.98, P = .03). When patients were divided into 5 temperature groups, mortality was lower with higher temperature (P for trend = .02). Conclusions: Early in ARDS, fever is associated with improved survival rates. Fever in the acute phase response to lung injury and its relationship to recovery may be an important factor in determining patients' outcome and warrants further study.

AB - Background: Little is known about the relationship between body temperature and outcomes in patients with acute respiratory distress syndrome (ARDS). A better understanding of this relationship may provide evidence for fever suppression or warming interventions, which are commonly applied in practice. Objective: To examine the relationship between body temperature and mortality in patients with ARDS. Methods: Secondary analysis of body temperature and mortality using data from the ARDS Network Fluid and Catheter Treatment Trial (n = 969). Body temperature at baseline and on study day 2, primary cause of ARDS, severity of illness, and 90-day mortality were analyzed by using multiple logistic regression. Results: Mean baseline temperature was 37.5°C (SD, 1.1°C; range, 27.2°C-40.7°C). At baseline, fever (≥ 38.3°C) was present in 23% and hypothermia (<36°C) in 5% of the patients. Body temperature was a significant predictor of 90-day mortality after primary cause of ARDS and score on the Acute Physiology and Chronic Health Evaluation III were adjusted for. Higher temperature was associated with decreased mortality: for every 1°C increase in baseline temperature, the odds of death decreased by 15% (odds ratio, 0.85; 95% CI, 0.73-0.98, P = .03). When patients were divided into 5 temperature groups, mortality was lower with higher temperature (P for trend = .02). Conclusions: Early in ARDS, fever is associated with improved survival rates. Fever in the acute phase response to lung injury and its relationship to recovery may be an important factor in determining patients' outcome and warrants further study.

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JO - American Journal of Critical Care

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