Body size and multiple myeloma mortality

A pooled analysis of 20 prospective studies

Lauren R. Teras, Cari M. Kitahara, Brenda M. Birmann, Patricia A. Hartge, Sophia S. Wang, Kim Robien, Alpa V. Patel, Hans Olov Adami, Elisabete Weiderpass, Graham G. Giles, Pramil N. Singh, Michael Alavanja, Laura E. Beane Freeman, Leslie Bernstein, Julie E. Buring, Graham A. Colditz, Gary E. Fraser, Susan M. Gapstur, J. Michael Gaziano, Edward Giovannucci & 15 others Jonathan N. Hofmann, Martha S. Linet, Gila Neta, Yikyung Park, Ulrike Peters, Philip S. Rosenberg, Catherine Schairer, Howard D. Sesso, Meir J. Stampfer, Kala Visvanathan, Emily White, Alicja Wolk, Anne Zeleniuch-Jacquotte, Amy Berrington de González, Mark P. Purdue

Research output: Contribution to journalArticle

Abstract

Multiple myeloma (MM) is a rare but highly fatal malignancy. High body weight is associated with this cancer, but several questions remain regarding the aetiological relevance of timing and location of body weight. To address these questions, we conducted a pooled analysis of MM mortality using 1·5 million participants (including 1388 MM deaths) from 20 prospective cohorts in the National Cancer Institute Cohort Consortium. Proportional hazards regression was used to calculate pooled multivariate hazard ratios (HRs) and 95% confidence intervals (CIs). Associations with elevated MM mortality were observed for higher early-adult body mass index (BMI; HR = 1·22, 95% CI: 1·09-1·35 per 5 kg/m2) and for higher cohort-entry BMI (HR 1·09, 95% CI: 1·03-1·16 per 5 kg/m2) and waist circumference (HR = 1·06, 95% CI: 1·02-1·10 per 5 cm). Women who were the heaviest, both in early adulthood (BMI 25+) and at cohort entry (BMI 30+) were at greater risk compared to those with BMI 18·5 ≤ 25 at both time points (HR = 1·95, 95% CI: 1·33-2·86). Waist-to-hip ratio and height were not associated with MM mortality. These observations suggest that overall, and possibly also central, obesity influence myeloma mortality, and women have the highest risk of death from this cancer if they remain heavy throughout adulthood.

Original languageEnglish (US)
Pages (from-to)667-676
Number of pages10
JournalBritish Journal of Haematology
Volume166
Issue number5
DOIs
StatePublished - 2014

Fingerprint

Body Size
Multiple Myeloma
Prospective Studies
Confidence Intervals
Mortality
Body Weight
Neoplasms
Waist-Hip Ratio
National Cancer Institute (U.S.)
Abdominal Obesity
Waist Circumference
Body Mass Index

Keywords

  • And anthropometry
  • Body mass index
  • Multiple myeloma
  • Pooled analysis
  • Prospective cohort study

ASJC Scopus subject areas

  • Hematology
  • Medicine(all)

Cite this

Teras, L. R., Kitahara, C. M., Birmann, B. M., Hartge, P. A., Wang, S. S., Robien, K., ... Purdue, M. P. (2014). Body size and multiple myeloma mortality: A pooled analysis of 20 prospective studies. British Journal of Haematology, 166(5), 667-676. https://doi.org/10.1111/bjh.12935

Body size and multiple myeloma mortality : A pooled analysis of 20 prospective studies. / Teras, Lauren R.; Kitahara, Cari M.; Birmann, Brenda M.; Hartge, Patricia A.; Wang, Sophia S.; Robien, Kim; Patel, Alpa V.; Adami, Hans Olov; Weiderpass, Elisabete; Giles, Graham G.; Singh, Pramil N.; Alavanja, Michael; Beane Freeman, Laura E.; Bernstein, Leslie; Buring, Julie E.; Colditz, Graham A.; Fraser, Gary E.; Gapstur, Susan M.; Gaziano, J. Michael; Giovannucci, Edward; Hofmann, Jonathan N.; Linet, Martha S.; Neta, Gila; Park, Yikyung; Peters, Ulrike; Rosenberg, Philip S.; Schairer, Catherine; Sesso, Howard D.; Stampfer, Meir J.; Visvanathan, Kala; White, Emily; Wolk, Alicja; Zeleniuch-Jacquotte, Anne; de González, Amy Berrington; Purdue, Mark P.

In: British Journal of Haematology, Vol. 166, No. 5, 2014, p. 667-676.

Research output: Contribution to journalArticle

Teras, LR, Kitahara, CM, Birmann, BM, Hartge, PA, Wang, SS, Robien, K, Patel, AV, Adami, HO, Weiderpass, E, Giles, GG, Singh, PN, Alavanja, M, Beane Freeman, LE, Bernstein, L, Buring, JE, Colditz, GA, Fraser, GE, Gapstur, SM, Gaziano, JM, Giovannucci, E, Hofmann, JN, Linet, MS, Neta, G, Park, Y, Peters, U, Rosenberg, PS, Schairer, C, Sesso, HD, Stampfer, MJ, Visvanathan, K, White, E, Wolk, A, Zeleniuch-Jacquotte, A, de González, AB & Purdue, MP 2014, 'Body size and multiple myeloma mortality: A pooled analysis of 20 prospective studies', British Journal of Haematology, vol. 166, no. 5, pp. 667-676. https://doi.org/10.1111/bjh.12935
Teras, Lauren R. ; Kitahara, Cari M. ; Birmann, Brenda M. ; Hartge, Patricia A. ; Wang, Sophia S. ; Robien, Kim ; Patel, Alpa V. ; Adami, Hans Olov ; Weiderpass, Elisabete ; Giles, Graham G. ; Singh, Pramil N. ; Alavanja, Michael ; Beane Freeman, Laura E. ; Bernstein, Leslie ; Buring, Julie E. ; Colditz, Graham A. ; Fraser, Gary E. ; Gapstur, Susan M. ; Gaziano, J. Michael ; Giovannucci, Edward ; Hofmann, Jonathan N. ; Linet, Martha S. ; Neta, Gila ; Park, Yikyung ; Peters, Ulrike ; Rosenberg, Philip S. ; Schairer, Catherine ; Sesso, Howard D. ; Stampfer, Meir J. ; Visvanathan, Kala ; White, Emily ; Wolk, Alicja ; Zeleniuch-Jacquotte, Anne ; de González, Amy Berrington ; Purdue, Mark P. / Body size and multiple myeloma mortality : A pooled analysis of 20 prospective studies. In: British Journal of Haematology. 2014 ; Vol. 166, No. 5. pp. 667-676.
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AU - Rosenberg, Philip S.

AU - Schairer, Catherine

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AU - Stampfer, Meir J.

AU - Visvanathan, Kala

AU - White, Emily

AU - Wolk, Alicja

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N2 - Multiple myeloma (MM) is a rare but highly fatal malignancy. High body weight is associated with this cancer, but several questions remain regarding the aetiological relevance of timing and location of body weight. To address these questions, we conducted a pooled analysis of MM mortality using 1·5 million participants (including 1388 MM deaths) from 20 prospective cohorts in the National Cancer Institute Cohort Consortium. Proportional hazards regression was used to calculate pooled multivariate hazard ratios (HRs) and 95% confidence intervals (CIs). Associations with elevated MM mortality were observed for higher early-adult body mass index (BMI; HR = 1·22, 95% CI: 1·09-1·35 per 5 kg/m2) and for higher cohort-entry BMI (HR 1·09, 95% CI: 1·03-1·16 per 5 kg/m2) and waist circumference (HR = 1·06, 95% CI: 1·02-1·10 per 5 cm). Women who were the heaviest, both in early adulthood (BMI 25+) and at cohort entry (BMI 30+) were at greater risk compared to those with BMI 18·5 ≤ 25 at both time points (HR = 1·95, 95% CI: 1·33-2·86). Waist-to-hip ratio and height were not associated with MM mortality. These observations suggest that overall, and possibly also central, obesity influence myeloma mortality, and women have the highest risk of death from this cancer if they remain heavy throughout adulthood.

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