Body mass index in early adulthood and dementia in late life: Findings from a pooled cohort

Adina Zeki Al Hazzouri, Eric Vittinghoff, Tina Hoang, Sherita H. Golden, Annette L. Fitzpatrick, Adina Zhang, Leslie Grasset, Kristine Yaffe

Research output: Contribution to journalArticlepeer-review


Introduction: To examine the independent association of body mass index (BMI) in early adulthood with dementia incidence among men and women. Methods: We studied 5104 older adults from the Cardiovascular Health Study (CHS) and the Health, Aging, and Body Composition (Health ABC) study. We imputed early adulthood and midlife BMI using a pooled parent cohort with complete adult lifespan coverage and previously established methods. Dementia was ascertained using criteria such as neuropsychological test battery, medical records, and dementia-related drug use. Pooled logistic regression (PLR) models were used. Results: Compared to women with normal BMI in early adulthood, the odds of dementia were higher among both overweight (odds ratio [OR] = 1.8; 95% confidence interval [CI] = 1.31 to 2.54) and obese (OR = 2.45; 95% CI = 1.47 to 4.06) women, independent of mid- and late-life BMI. Similar relationship was observed in men. Conclusions: With the growing obesity epidemic among US adults, efforts aimed at reducing dementia may need to begin obesity prevention and treatment early in the life course.

Original languageEnglish (US)
Pages (from-to)1798-1807
Number of pages10
JournalAlzheimer's and Dementia
Issue number11
StatePublished - Nov 2021


  • body mass index
  • cohort
  • dementia
  • life course

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience


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