TY - JOUR
T1 - Body mass index and weight change are associated with adult lung function trajectories
T2 - The prospective ECRHS study
AU - Peralta, Gabriela P.
AU - Marcon, Alessandro
AU - Carsin, Anne Elie
AU - Abramson, Michael J.
AU - Accordini, Simone
AU - Amaral, André F.S.
AU - Antó, Josep M.
AU - Bowatte, Gayan
AU - Burney, Peter
AU - Corsico, Angelo
AU - Demoly, Pascal
AU - Dharmage, Shyamali
AU - Forsberg, Bertil
AU - Fuertes, Elaine
AU - Garcia-Larsen, Vanessa
AU - Gíslason, Thorarinn
AU - Gullón, José Antonio
AU - Heinrich, Joachim
AU - Holm, Mathias
AU - Jarvis, Deborah L.
AU - Janson, Christer
AU - Jogi, Rain
AU - Johannessen, Ane
AU - Leynaert, Bénédicte
AU - Rovira, Jesús Martínez Moratalla
AU - Nowak, Dennis
AU - Probst-Hensch, Nicole
AU - Raherison, Chantal
AU - Sánchez-Ramos, José Luis
AU - Sigsgaard, Torben
AU - Siroux, Valérie
AU - Squillacioti, Giulia
AU - Urrutia, Isabel
AU - Weyler, Joost
AU - Zock, Jan Paul
AU - Garcia-Aymerich, Judith
N1 - Publisher Copyright:
© Author(s) (or their employer(s)) 2020.
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Background: Previous studies have reported an association between weight increase and excess lung function decline in young adults followed for short periods. We aimed to estimate lung function trajectories during adulthood from 20-year weight change profiles using data from the population-based European Community Respiratory Health Survey (ECRHS). Methods: We included 3673 participants recruited at age 20-44 years with repeated measurements of weight and lung function (forced vital capacity (FVC), forced expiratory volume in 1 s (FEV 1)) in three study waves (1991-93, 1999-2003, 2010-14) until they were 39-67 years of age. We classified subjects into weight change profiles according to baseline body mass index (BMI) categories and weight change over 20 years. We estimated trajectories of lung function over time as a function of weight change profiles using population-averaged generalised estimating equations. Results: In individuals with normal BMI, overweight and obesity at baseline, moderate (0.25-1 kg/year) and high weight gain (>1 kg/year) during follow-up were associated with accelerated FVC and FEV 1 declines. Compared with participants with baseline normal BMI and stable weight (±0.25 kg/year), obese individuals with high weight gain during follow-up had -1011 mL (95% CI -1.259 to -763) lower estimated FVC at 65 years despite similar estimated FVC levels at 25 years. Obese individuals at baseline who lost weight (<-0.25 kg/year) exhibited an attenuation of FVC and FEV 1 declines. We found no association between weight change profiles and FEV 1 /FVC decline. Conclusion: Moderate and high weight gain over 20 years was associated with accelerated lung function decline, while weight loss was related to its attenuation. Control of weight gain is important for maintaining good lung function in adult life.
AB - Background: Previous studies have reported an association between weight increase and excess lung function decline in young adults followed for short periods. We aimed to estimate lung function trajectories during adulthood from 20-year weight change profiles using data from the population-based European Community Respiratory Health Survey (ECRHS). Methods: We included 3673 participants recruited at age 20-44 years with repeated measurements of weight and lung function (forced vital capacity (FVC), forced expiratory volume in 1 s (FEV 1)) in three study waves (1991-93, 1999-2003, 2010-14) until they were 39-67 years of age. We classified subjects into weight change profiles according to baseline body mass index (BMI) categories and weight change over 20 years. We estimated trajectories of lung function over time as a function of weight change profiles using population-averaged generalised estimating equations. Results: In individuals with normal BMI, overweight and obesity at baseline, moderate (0.25-1 kg/year) and high weight gain (>1 kg/year) during follow-up were associated with accelerated FVC and FEV 1 declines. Compared with participants with baseline normal BMI and stable weight (±0.25 kg/year), obese individuals with high weight gain during follow-up had -1011 mL (95% CI -1.259 to -763) lower estimated FVC at 65 years despite similar estimated FVC levels at 25 years. Obese individuals at baseline who lost weight (<-0.25 kg/year) exhibited an attenuation of FVC and FEV 1 declines. We found no association between weight change profiles and FEV 1 /FVC decline. Conclusion: Moderate and high weight gain over 20 years was associated with accelerated lung function decline, while weight loss was related to its attenuation. Control of weight gain is important for maintaining good lung function in adult life.
KW - BMI
KW - adults
KW - epidemiology
KW - lung function
KW - obesity
KW - weight change
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U2 - 10.1136/thoraxjnl-2019-213880
DO - 10.1136/thoraxjnl-2019-213880
M3 - Article
C2 - 32098862
AN - SCOPUS:85081368670
SN - 0040-6376
VL - 75
SP - 313
EP - 320
JO - Thorax
JF - Thorax
IS - 4
ER -