Body mass index and weight change are associated with adult lung function trajectories: The prospective ECRHS study

Gabriela P. Peralta, Alessandro Marcon, Anne Elie Carsin, Michael J. Abramson, Simone Accordini, André F.S. Amaral, Josep M. Antó, Gayan Bowatte, Peter Burney, Angelo Corsico, Pascal Demoly, Shyamali Dharmage, Bertil Forsberg, Elaine Fuertes, Vanessa Garcia-Larsen, Thorarinn Gíslason, José Antonio Gullón, Joachim Heinrich, Mathias Holm, Deborah L. JarvisChrister Janson, Rain Jogi, Ane Johannessen, Bénédicte Leynaert, Jesús Martínez Moratalla Rovira, Dennis Nowak, Nicole Probst-Hensch, Chantal Raherison, José Luis Sánchez-Ramos, Torben Sigsgaard, Valérie Siroux, Giulia Squillacioti, Isabel Urrutia, Joost Weyler, Jan Paul Zock, Judith Garcia-Aymerich

Research output: Contribution to journalArticle

Abstract

Background: Previous studies have reported an association between weight increase and excess lung function decline in young adults followed for short periods. We aimed to estimate lung function trajectories during adulthood from 20-year weight change profiles using data from the population-based European Community Respiratory Health Survey (ECRHS). Methods: We included 3673 participants recruited at age 20-44 years with repeated measurements of weight and lung function (forced vital capacity (FVC), forced expiratory volume in 1 s (FEV 1)) in three study waves (1991-93, 1999-2003, 2010-14) until they were 39-67 years of age. We classified subjects into weight change profiles according to baseline body mass index (BMI) categories and weight change over 20 years. We estimated trajectories of lung function over time as a function of weight change profiles using population-averaged generalised estimating equations. Results: In individuals with normal BMI, overweight and obesity at baseline, moderate (0.25-1 kg/year) and high weight gain (>1 kg/year) during follow-up were associated with accelerated FVC and FEV 1 declines. Compared with participants with baseline normal BMI and stable weight (±0.25 kg/year), obese individuals with high weight gain during follow-up had -1011 mL (95% CI -1.259 to -763) lower estimated FVC at 65 years despite similar estimated FVC levels at 25 years. Obese individuals at baseline who lost weight (<-0.25 kg/year) exhibited an attenuation of FVC and FEV 1 declines. We found no association between weight change profiles and FEV 1 /FVC decline. Conclusion: Moderate and high weight gain over 20 years was associated with accelerated lung function decline, while weight loss was related to its attenuation. Control of weight gain is important for maintaining good lung function in adult life.

Original languageEnglish (US)
Pages (from-to)313-320
Number of pages8
JournalThorax
Volume75
Issue number4
DOIs
StatePublished - Apr 1 2020

Keywords

  • BMI
  • adults
  • epidemiology
  • lung function
  • obesity
  • weight change

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Peralta, G. P., Marcon, A., Carsin, A. E., Abramson, M. J., Accordini, S., Amaral, A. F. S., Antó, J. M., Bowatte, G., Burney, P., Corsico, A., Demoly, P., Dharmage, S., Forsberg, B., Fuertes, E., Garcia-Larsen, V., Gíslason, T., Gullón, J. A., Heinrich, J., Holm, M., ... Garcia-Aymerich, J. (2020). Body mass index and weight change are associated with adult lung function trajectories: The prospective ECRHS study. Thorax, 75(4), 313-320. https://doi.org/10.1136/thoraxjnl-2019-213880