Body mass index and mortality in women

Follow-up of the Canadian National Breast Screening Study cohort

M. G. Jain, A. B. Miller, T. E. Rohan, J. T. Rehm, S. J. Bondy, M. J. Ashley, Joanna E Cohen, R. G. Ferrence

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: The present study was conducted to examine the relationship between obesity and all-cause mortality in women. STUDY DESIGN AND SETTINGS: The subjects were women enrolled from 1980 to 1985 in a Canadian randomized trial, the National Breast Screening Study (NBSS) to evaluate the efficacy of mammographie screening. Mortality was ascertained by record linkage to the Canadian Mortality Data Base. Hazard ratios (HR) for the association between body mass index (BMI) and all-cause mortality were obtained from Cox proportional hazard regression models. RESULTS: During an average follow-up period of 16.5 years, 2566 deaths were identified among the 49165 women, age 40-59 y at enrolment. The risk of all-cause death increased linearly above a BMI of 22 kg/m2 and the trend was statistically significant. The HR (and 95% confidence intervals) in the various categories of BMI (kg/m2) were: BMI <18.5: 1.12 (0.99-1.25); BMI 18.5-21.9: 1.00 (reference); BMI 22-24.9: 1.15 (1.11-1.18); BMI 25.0-27.9: 1.28 (1.24-1.32); BMI 28.0-29.9: 1.34 (1.29-1.39); BMI 30.0-34.9: 1.30 (1.25-1.35); and BMI ≥ 35.0: 1.40 (1.33-1.47). CONCLUSION: This study confirms the association of high BMI with increased all-cause mortality in women.

Original languageEnglish (US)
Pages (from-to)792-797
Number of pages6
JournalInternational Journal of Obesity
Volume29
Issue number7
DOIs
StatePublished - Jul 2005
Externally publishedYes

Fingerprint

cohort studies
breasts
body mass index
Breast
Body Mass Index
Cohort Studies
screening
Mortality
death
Proportional Hazards Models
confidence interval
Cause of Death
obesity
Obesity
Databases
Confidence Intervals

Keywords

  • Body mass index
  • Cohort
  • Mortality
  • Trial
  • Women

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Jain, M. G., Miller, A. B., Rohan, T. E., Rehm, J. T., Bondy, S. J., Ashley, M. J., ... Ferrence, R. G. (2005). Body mass index and mortality in women: Follow-up of the Canadian National Breast Screening Study cohort. International Journal of Obesity, 29(7), 792-797. https://doi.org/10.1038/sj.ijo.0802952

Body mass index and mortality in women : Follow-up of the Canadian National Breast Screening Study cohort. / Jain, M. G.; Miller, A. B.; Rohan, T. E.; Rehm, J. T.; Bondy, S. J.; Ashley, M. J.; Cohen, Joanna E; Ferrence, R. G.

In: International Journal of Obesity, Vol. 29, No. 7, 07.2005, p. 792-797.

Research output: Contribution to journalArticle

Jain, M. G. ; Miller, A. B. ; Rohan, T. E. ; Rehm, J. T. ; Bondy, S. J. ; Ashley, M. J. ; Cohen, Joanna E ; Ferrence, R. G. / Body mass index and mortality in women : Follow-up of the Canadian National Breast Screening Study cohort. In: International Journal of Obesity. 2005 ; Vol. 29, No. 7. pp. 792-797.
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