Body mass index and early CD4 T-cell recovery among adults initiating antiretroviral therapy in North America, 1998-2010

for the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD)

Research output: Contribution to journalArticle

Abstract

Objectives: Adipose tissue affects several aspects of the cellular immune system, but prior epidemiological studies have differed on whether a higher body mass index (BMI) promotes CD4 T-cell recovery on antiretroviral therapy (ART). The objective of this analysis was to assess the relationship between BMI at ART initiation and early changes in CD4 T-cell count. Methods: We used the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) data set to analyse the relationship between pre-treatment BMI and 12-month CD4 T-cell recovery among adults who started ART between 1998 and 2010 and maintained HIV-1 RNA levels 2) and 15% were obese (BMI >30kg/m2). Pretreatment BMI was associated with 12-month CD4 T-cell change (P2, a BMI of 30kg/m2 was associated with a 36cells/μL [95% confidence interval (CI) 14, 59cells/μL] greater CD4 T-cell count recovery among women and a 19cells/μL (95% CI 9, 30cells/μL) greater recovery among men at 12 months. At a BMI>30kg/m2, the observed benefit was attenuated among men to a greater degree than among women, although this difference was not statistically significant. Conclusions: A BMI of approximately 30kg/m2 at ART initiation was associated with greater CD4 T-cell recovery at 12 months compared with higher or lower BMI values, suggesting that body composition may affect peripheral CD4 T-cell recovery.

Original languageEnglish (US)
Pages (from-to)572-577
Number of pages6
JournalHIV Medicine
Volume16
Issue number9
DOIs
StatePublished - Oct 1 2015

Fingerprint

North America
Body Mass Index
T-Lymphocytes
Therapeutics
CD4 Lymphocyte Count
Confidence Intervals
Body Composition
Adipose Tissue
HIV-1
Epidemiologic Studies
Immune System
Acquired Immunodeficiency Syndrome
Research Design
RNA

Keywords

  • Antiretroviral therapy
  • HIV
  • Immune reconsitition
  • Nutrition
  • Obesity

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)
  • Health Policy

Cite this

for the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) (2015). Body mass index and early CD4 T-cell recovery among adults initiating antiretroviral therapy in North America, 1998-2010. HIV Medicine, 16(9), 572-577. https://doi.org/10.1111/hiv.12259

Body mass index and early CD4 T-cell recovery among adults initiating antiretroviral therapy in North America, 1998-2010. / for the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD).

In: HIV Medicine, Vol. 16, No. 9, 01.10.2015, p. 572-577.

Research output: Contribution to journalArticle

for the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) 2015, 'Body mass index and early CD4 T-cell recovery among adults initiating antiretroviral therapy in North America, 1998-2010', HIV Medicine, vol. 16, no. 9, pp. 572-577. https://doi.org/10.1111/hiv.12259
for the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD). Body mass index and early CD4 T-cell recovery among adults initiating antiretroviral therapy in North America, 1998-2010. HIV Medicine. 2015 Oct 1;16(9):572-577. https://doi.org/10.1111/hiv.12259
for the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD). / Body mass index and early CD4 T-cell recovery among adults initiating antiretroviral therapy in North America, 1998-2010. In: HIV Medicine. 2015 ; Vol. 16, No. 9. pp. 572-577.
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AU - for the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD)

AU - Koethe, J. R.

AU - Jenkins, C. A.

AU - Lau, Bryan M

AU - Shepherd, B. E.

AU - Silverberg, M. J.

AU - Brown, Todd T

AU - Blashill, A. J.

AU - Anema, A.

AU - Willig, A.

AU - Stinnette, S.

AU - Napravnik, S.

AU - Gill, J.

AU - Crane, H. M.

AU - Sterling, T. R.

PY - 2015/10/1

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N2 - Objectives: Adipose tissue affects several aspects of the cellular immune system, but prior epidemiological studies have differed on whether a higher body mass index (BMI) promotes CD4 T-cell recovery on antiretroviral therapy (ART). The objective of this analysis was to assess the relationship between BMI at ART initiation and early changes in CD4 T-cell count. Methods: We used the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) data set to analyse the relationship between pre-treatment BMI and 12-month CD4 T-cell recovery among adults who started ART between 1998 and 2010 and maintained HIV-1 RNA levels 2) and 15% were obese (BMI >30kg/m2). Pretreatment BMI was associated with 12-month CD4 T-cell change (P2, a BMI of 30kg/m2 was associated with a 36cells/μL [95% confidence interval (CI) 14, 59cells/μL] greater CD4 T-cell count recovery among women and a 19cells/μL (95% CI 9, 30cells/μL) greater recovery among men at 12 months. At a BMI>30kg/m2, the observed benefit was attenuated among men to a greater degree than among women, although this difference was not statistically significant. Conclusions: A BMI of approximately 30kg/m2 at ART initiation was associated with greater CD4 T-cell recovery at 12 months compared with higher or lower BMI values, suggesting that body composition may affect peripheral CD4 T-cell recovery.

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KW - HIV

KW - Immune reconsitition

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