Body mass and stage of breast cancer at diagnosis

Yadong Cui, Maura K. Whiteman, Jodi A. Flaws, Patricia Langenberg, Katherine H. Tkaczuk, Trudy L. Bush

Research output: Contribution to journalArticle

Abstract

Obesity is a well-known risk factor for postmenopausal breast cancer. In contrast, the relationship between obesity and stage of breast cancer at diagnosis is less clear. We hypothesized that increased breast size in obese women may delay discovery of breast tumors. Thus, the purpose of our study was to examine whether there is an association between body mass and stage of breast cancer at diagnosis using hospital medical records. Newly diagnosed breast cancer cases (n = 966) in the Baltimore metropolitan area from 1991 to 1997 were included in our study. Patient information including age, ethnicity, weight, height and pathology data were obtained from hospital medical records. High body mass was significantly associated with late stage of breast cancer at diagnosis. Women who were obese (body mass index [BMI] ≥ 27.3) were more likely to be at an advanced stage at diagnosis compared with women with a BMI of <27.3 (multivariate-adjusted odds ratio [OR] 1.57, 95% confidence interval [CI] 1.15-2.14). The association between body mass and stage at diagnosis was stronger among women younger than 50 years (OR 2.34, 95% CI 1.34-4.08) compared with women 50 years or older (OR 1.30, 95% CI 0.89-1.91). Our study suggests that higher body mass is associated with advanced stage of breast cancer at diagnosis. This finding may be of considerable concern, given the increasing prevalence of obesity in women in the United States and the poor prognosis associated with late-stage tumors.

Original languageEnglish (US)
Pages (from-to)279-283
Number of pages5
JournalInternational Journal of Cancer
Volume98
Issue number2
DOIs
StatePublished - Mar 10 2002
Externally publishedYes

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Breast Neoplasms
Hospital Records
Obesity
Odds Ratio
Confidence Intervals
Medical Records
Body Mass Index
Baltimore
Breast
Pathology
Weights and Measures
Neoplasms

Keywords

  • Body mass
  • Breast cancer
  • Obesity
  • Stage

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cui, Y., Whiteman, M. K., Flaws, J. A., Langenberg, P., Tkaczuk, K. H., & Bush, T. L. (2002). Body mass and stage of breast cancer at diagnosis. International Journal of Cancer, 98(2), 279-283. https://doi.org/10.1002/ijc.10209

Body mass and stage of breast cancer at diagnosis. / Cui, Yadong; Whiteman, Maura K.; Flaws, Jodi A.; Langenberg, Patricia; Tkaczuk, Katherine H.; Bush, Trudy L.

In: International Journal of Cancer, Vol. 98, No. 2, 10.03.2002, p. 279-283.

Research output: Contribution to journalArticle

Cui, Y, Whiteman, MK, Flaws, JA, Langenberg, P, Tkaczuk, KH & Bush, TL 2002, 'Body mass and stage of breast cancer at diagnosis', International Journal of Cancer, vol. 98, no. 2, pp. 279-283. https://doi.org/10.1002/ijc.10209
Cui Y, Whiteman MK, Flaws JA, Langenberg P, Tkaczuk KH, Bush TL. Body mass and stage of breast cancer at diagnosis. International Journal of Cancer. 2002 Mar 10;98(2):279-283. https://doi.org/10.1002/ijc.10209
Cui, Yadong ; Whiteman, Maura K. ; Flaws, Jodi A. ; Langenberg, Patricia ; Tkaczuk, Katherine H. ; Bush, Trudy L. / Body mass and stage of breast cancer at diagnosis. In: International Journal of Cancer. 2002 ; Vol. 98, No. 2. pp. 279-283.
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