TY - JOUR
T1 - Body composition status and the risk of migraine
T2 - A meta-analysis
AU - Gelaye, Bizu
AU - Sacco, Simona
AU - Brown, Wendy J.
AU - Nitchie, Haley L.
AU - Ornello, Raffaele
AU - Peterlin, B. Lee
N1 - Funding Information:
DiSCLOSURE B. Gelaye has consulted for Egalet Corporation for a project unrelated to the current manuscript. S. Sacco, W. Brown, H. Nitchie, and R. Ornello report no disclosures relevant to the manuscript. B. Peterlin: funding by NIH/NINDS (grant #K23-NS078345); serves on the editorial boards for Neurology and as an associate editor for Headache. Go to Neurology.org for full disclosures.
Publisher Copyright:
© 2017 American Academy of Neurology.
PY - 2017/5/9
Y1 - 2017/5/9
N2 - Objective: To evaluate the association between migraine and body composition status as estimated based on body mass index and WHO physical status categories. Methods: Systematic electronic database searches were conducted for relevant studies. Two independent reviewers performed data extraction and quality appraisal. Odds ratios (OR) and confidence intervals (CI) were pooled using a random effects model. Significant values, weighted effect sizes, and tests of homogeneity of variance were calculated. Results: A total of 12 studies, encompassing data from 288,981 unique participants, were included. The age- and sex-adjusted pooled risk of migraine in those with obesity was increased by 27% compared with those of normal weight (odds ratio [OR] 1.27; 95% confidence interval [CI] 1.16-1.37, p < 0.001) and remained increased after multivariate adjustments. Although the age- and sex-adjusted pooled migraine risk was increased in overweight individuals (OR 1.08; 95% CI 1.04, 1.12, p < 0.001), significance was lost after multivariate adjustments. The age- and sex-adjusted pooled risk of migraine in underweight individuals was marginally increased by 13% compared with those of normal weight (OR 1.13; 95% CI 1.02, 1.24, p < 0.001) and remained increased after multivariate adjustments. Conclusions: The current body of evidence shows that the risk of migraine is increased in obese and underweight individuals. Studies are needed to confirm whether interventions that modify obesity status decrease the risk of migraine.
AB - Objective: To evaluate the association between migraine and body composition status as estimated based on body mass index and WHO physical status categories. Methods: Systematic electronic database searches were conducted for relevant studies. Two independent reviewers performed data extraction and quality appraisal. Odds ratios (OR) and confidence intervals (CI) were pooled using a random effects model. Significant values, weighted effect sizes, and tests of homogeneity of variance were calculated. Results: A total of 12 studies, encompassing data from 288,981 unique participants, were included. The age- and sex-adjusted pooled risk of migraine in those with obesity was increased by 27% compared with those of normal weight (odds ratio [OR] 1.27; 95% confidence interval [CI] 1.16-1.37, p < 0.001) and remained increased after multivariate adjustments. Although the age- and sex-adjusted pooled migraine risk was increased in overweight individuals (OR 1.08; 95% CI 1.04, 1.12, p < 0.001), significance was lost after multivariate adjustments. The age- and sex-adjusted pooled risk of migraine in underweight individuals was marginally increased by 13% compared with those of normal weight (OR 1.13; 95% CI 1.02, 1.24, p < 0.001) and remained increased after multivariate adjustments. Conclusions: The current body of evidence shows that the risk of migraine is increased in obese and underweight individuals. Studies are needed to confirm whether interventions that modify obesity status decrease the risk of migraine.
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U2 - 10.1212/WNL.0000000000003919
DO - 10.1212/WNL.0000000000003919
M3 - Article
C2 - 28404807
AN - SCOPUS:85019856108
SN - 0028-3878
VL - 88
SP - 1795
EP - 1804
JO - Neurology
JF - Neurology
IS - 19
ER -