Body brain life: A randomized controlled trial of an online dementia risk reduction intervention in middle-aged adults at risk of Alzheimer's disease

Kaarin J. Anstey; Alex Bahar-Fuchs; Pushpani Herath; Sarang Kim; Richard Burns; George W. Rebok; Nicolas Cherbuin

doi:10.1016/j.trci.2015.04.003

Body brain life: A randomized controlled trial of an online dementia risk reduction intervention in middle-aged adults at risk of Alzheimer's disease

Kaarin J. Anstey, Alex Bahar-Fuchs, Pushpani Herath, Sarang Kim, Richard Burns, George W. Rebok, Nicolas Cherbuin

School of Medicine

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Objective To examine the efficacy of body brain life (BBL), a 12-week online dementia risk reduction intervention. Methods BBL was evaluated in a randomized controlled trial in 176 middle-aged adults with >2 risk factors and <2 protective factors for Alzheimer's disease (AD) assessed on a brief screening instrument. Participants were randomized to BBL, BBL plus face-to-face group sessions (BBL + FF) or active control (control). Score on the Australian National University-Alzheimer's disease risk index (ANU-ADRI), a validated index of AD risk, was the primary outcome measure assessed at baseline, 12, and 26 weeks. Results A group by time interaction at 26 weeks showed a significant reduction in ANU-ADRI score for BBL compared with control. Planned contrasts showed the BBL and BBL + FF groups had improvement in ANU-ADRI scores at 12 weeks (BBL + FF: z = -0.25; P =.021; BBL: z = -0.25; P =.008) and 26 weeks (BBL + FF: z = -0.48; P <.001; BBL: z = -0.28; P =.004) due to increase in protective factors. Conclusions This short intervention resulted in dementia risk reduction. Online dementia risk reduction interventions show promise for reducing the overall dementia risk in middle-aged adults with multiple risk factors. Clinical Trial Registration: The study is registered under Trial Registration: Reg. # ACTRN12612000147886.

Original language	English (US)
Pages (from-to)	72-80
Number of pages	9
Journal	Alzheimer's and Dementia: Translational Research and Clinical Interventions
Volume	1
Issue number	1
DOIs	https://doi.org/10.1016/j.trci.2015.04.003
State	Published - Oct 14 2015

Keywords

Behavior change
Cognitive activity
Dementia prevention
Intervention
Risk factor
Risk reduction
Social engagement

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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10.1016/j.trci.2015.04.003

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Anstey, K. J., Bahar-Fuchs, A., Herath, P., Kim, S., Burns, R., Rebok, G. W., & Cherbuin, N. (2015). Body brain life: A randomized controlled trial of an online dementia risk reduction intervention in middle-aged adults at risk of Alzheimer's disease. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 1(1), 72-80. https://doi.org/10.1016/j.trci.2015.04.003

Body brain life: A randomized controlled trial of an online dementia risk reduction intervention in middle-aged adults at risk of Alzheimer's disease. / Anstey, Kaarin J.; Bahar-Fuchs, Alex; Herath, Pushpani et al.
In: Alzheimer's and Dementia: Translational Research and Clinical Interventions, Vol. 1, No. 1, 14.10.2015, p. 72-80.

Research output: Contribution to journal › Article › peer-review

Anstey, KJ, Bahar-Fuchs, A, Herath, P, Kim, S, Burns, R, Rebok, GW & Cherbuin, N 2015, 'Body brain life: A randomized controlled trial of an online dementia risk reduction intervention in middle-aged adults at risk of Alzheimer's disease', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 1, no. 1, pp. 72-80. https://doi.org/10.1016/j.trci.2015.04.003

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abstract = "Objective To examine the efficacy of body brain life (BBL), a 12-week online dementia risk reduction intervention. Methods BBL was evaluated in a randomized controlled trial in 176 middle-aged adults with >2 risk factors and <2 protective factors for Alzheimer's disease (AD) assessed on a brief screening instrument. Participants were randomized to BBL, BBL plus face-to-face group sessions (BBL + FF) or active control (control). Score on the Australian National University-Alzheimer's disease risk index (ANU-ADRI), a validated index of AD risk, was the primary outcome measure assessed at baseline, 12, and 26 weeks. Results A group by time interaction at 26 weeks showed a significant reduction in ANU-ADRI score for BBL compared with control. Planned contrasts showed the BBL and BBL + FF groups had improvement in ANU-ADRI scores at 12 weeks (BBL + FF: z = -0.25; P =.021; BBL: z = -0.25; P =.008) and 26 weeks (BBL + FF: z = -0.48; P <.001; BBL: z = -0.28; P =.004) due to increase in protective factors. Conclusions This short intervention resulted in dementia risk reduction. Online dementia risk reduction interventions show promise for reducing the overall dementia risk in middle-aged adults with multiple risk factors. Clinical Trial Registration: The study is registered under Trial Registration: Reg. # ACTRN12612000147886.",

keywords = "Behavior change, Cognitive activity, Dementia prevention, Intervention, Risk factor, Risk reduction, Social engagement",

author = "Anstey, {Kaarin J.} and Alex Bahar-Fuchs and Pushpani Herath and Sarang Kim and Richard Burns and Rebok, {George W.} and Nicolas Cherbuin",

note = "Funding Information: K.J.A. and A.B.-F. are funded by NHMRC Research Fellowship #1002560 and #1072688. N.C. is funded by an ARC Future Fellowship #120100227. The research is supported by the Dementia Collaborative Research Centres. R.A.B. is supported by the Australian Research Council Centre of Excellence in Population Ageing Research (project #CE110001029). The funders had no role in this research. We acknowledge Lily Jenkins and Jocelyn Barnett for their assistance. K.J.A. had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Publisher Copyright: {\textcopyright} 2015 The Authors.",

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AU - Herath, Pushpani

AU - Kim, Sarang

AU - Burns, Richard

AU - Rebok, George W.

AU - Cherbuin, Nicolas

N1 - Funding Information: K.J.A. and A.B.-F. are funded by NHMRC Research Fellowship #1002560 and #1072688. N.C. is funded by an ARC Future Fellowship #120100227. The research is supported by the Dementia Collaborative Research Centres. R.A.B. is supported by the Australian Research Council Centre of Excellence in Population Ageing Research (project #CE110001029). The funders had no role in this research. We acknowledge Lily Jenkins and Jocelyn Barnett for their assistance. K.J.A. had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Publisher Copyright: © 2015 The Authors.

PY - 2015/10/14

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N2 - Objective To examine the efficacy of body brain life (BBL), a 12-week online dementia risk reduction intervention. Methods BBL was evaluated in a randomized controlled trial in 176 middle-aged adults with >2 risk factors and <2 protective factors for Alzheimer's disease (AD) assessed on a brief screening instrument. Participants were randomized to BBL, BBL plus face-to-face group sessions (BBL + FF) or active control (control). Score on the Australian National University-Alzheimer's disease risk index (ANU-ADRI), a validated index of AD risk, was the primary outcome measure assessed at baseline, 12, and 26 weeks. Results A group by time interaction at 26 weeks showed a significant reduction in ANU-ADRI score for BBL compared with control. Planned contrasts showed the BBL and BBL + FF groups had improvement in ANU-ADRI scores at 12 weeks (BBL + FF: z = -0.25; P =.021; BBL: z = -0.25; P =.008) and 26 weeks (BBL + FF: z = -0.48; P <.001; BBL: z = -0.28; P =.004) due to increase in protective factors. Conclusions This short intervention resulted in dementia risk reduction. Online dementia risk reduction interventions show promise for reducing the overall dementia risk in middle-aged adults with multiple risk factors. Clinical Trial Registration: The study is registered under Trial Registration: Reg. # ACTRN12612000147886.

AB - Objective To examine the efficacy of body brain life (BBL), a 12-week online dementia risk reduction intervention. Methods BBL was evaluated in a randomized controlled trial in 176 middle-aged adults with >2 risk factors and <2 protective factors for Alzheimer's disease (AD) assessed on a brief screening instrument. Participants were randomized to BBL, BBL plus face-to-face group sessions (BBL + FF) or active control (control). Score on the Australian National University-Alzheimer's disease risk index (ANU-ADRI), a validated index of AD risk, was the primary outcome measure assessed at baseline, 12, and 26 weeks. Results A group by time interaction at 26 weeks showed a significant reduction in ANU-ADRI score for BBL compared with control. Planned contrasts showed the BBL and BBL + FF groups had improvement in ANU-ADRI scores at 12 weeks (BBL + FF: z = -0.25; P =.021; BBL: z = -0.25; P =.008) and 26 weeks (BBL + FF: z = -0.48; P <.001; BBL: z = -0.28; P =.004) due to increase in protective factors. Conclusions This short intervention resulted in dementia risk reduction. Online dementia risk reduction interventions show promise for reducing the overall dementia risk in middle-aged adults with multiple risk factors. Clinical Trial Registration: The study is registered under Trial Registration: Reg. # ACTRN12612000147886.

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Body brain life: A randomized controlled trial of an online dementia risk reduction intervention in middle-aged adults at risk of Alzheimer's disease

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Keywords

ASJC Scopus subject areas

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