BMP signaling mediates effects of exercise on hippocampal neurogenesis and cognition in mice

Kevin T. Gobeske, Sunit Das, Michael A. Bonaguidi, Craig Weiss, Jelena Radulovic, John F. Disterhoft, John A. Kessler

Research output: Contribution to journalArticle

Abstract

Exposure to exercise or to environmental enrichment increases the generation of new neurons in the adult hippocampus and promotes certain kinds of learning and memory. While the precise role of neurogenesis in cognition has been debated intensely, comparatively few studies have addressed the mechanisms linking environmental exposures to cellular and behavioral outcomes. Here we show that bone morphogenetic protein (BMP) signaling mediates the effects of exercise on neurogenesis and cognition in the adult hippocampus. Elective exercise reduces levels of hippocampal BMP signaling before and during its promotion of neurogenesis and learning. Transgenic mice with decreased BMP signaling or wild type mice infused with a BMP inhibitor both exhibit remarkable gains in hippocampal cognitive performance and neurogenesis, mirroring the effects of exercise. Conversely, transgenic mice with increased BMP signaling have diminished hippocampal neurogenesis and impaired cognition. Exercise exposure does not rescue these deficits, suggesting that reduced BMP signaling is required for environmental effects on neurogenesis and learning. Together, these observations show that BMP signaling is a fundamental mechanism linking environmental exposure with changes in cognitive function and cellular properties in the hippocampus.

Original languageEnglish (US)
Article numbere7506
JournalPLoS One
Volume4
Issue number10
DOIs
StatePublished - Oct 20 2009
Externally publishedYes

Fingerprint

bone morphogenetic proteins
Bone Morphogenetic Proteins
neurogenesis
Neurogenesis
cognition
Cognition
exercise
mice
hippocampus
Hippocampus
learning
Environmental Exposure
Learning
Transgenic Mice
genetically modified organisms
environmental enrichment
Neurons
Environmental impact
neurons
Data storage equipment

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Gobeske, K. T., Das, S., Bonaguidi, M. A., Weiss, C., Radulovic, J., Disterhoft, J. F., & Kessler, J. A. (2009). BMP signaling mediates effects of exercise on hippocampal neurogenesis and cognition in mice. PLoS One, 4(10), [e7506]. https://doi.org/10.1371/journal.pone.0007506

BMP signaling mediates effects of exercise on hippocampal neurogenesis and cognition in mice. / Gobeske, Kevin T.; Das, Sunit; Bonaguidi, Michael A.; Weiss, Craig; Radulovic, Jelena; Disterhoft, John F.; Kessler, John A.

In: PLoS One, Vol. 4, No. 10, e7506, 20.10.2009.

Research output: Contribution to journalArticle

Gobeske, KT, Das, S, Bonaguidi, MA, Weiss, C, Radulovic, J, Disterhoft, JF & Kessler, JA 2009, 'BMP signaling mediates effects of exercise on hippocampal neurogenesis and cognition in mice', PLoS One, vol. 4, no. 10, e7506. https://doi.org/10.1371/journal.pone.0007506
Gobeske KT, Das S, Bonaguidi MA, Weiss C, Radulovic J, Disterhoft JF et al. BMP signaling mediates effects of exercise on hippocampal neurogenesis and cognition in mice. PLoS One. 2009 Oct 20;4(10). e7506. https://doi.org/10.1371/journal.pone.0007506
Gobeske, Kevin T. ; Das, Sunit ; Bonaguidi, Michael A. ; Weiss, Craig ; Radulovic, Jelena ; Disterhoft, John F. ; Kessler, John A. / BMP signaling mediates effects of exercise on hippocampal neurogenesis and cognition in mice. In: PLoS One. 2009 ; Vol. 4, No. 10.
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