Blueberry-enriched diet protects rat heart from ischemic damage

Ismayil Ahmet, Edward Spangler, Barbara Shukitt-Hale, Magdalena Juhaszova, Steven J. Sollott, James A. Joseph, Donald K. Ingram, Mark Talan

Research output: Contribution to journalArticle

Abstract

Objectives: To assess the cardioprotective properties of a blueberry enriched diet (BD). Background: Reactive oxygen species (ROS) play a major role in ischemia-related myocardial injury. The attempts to use synthetic antioxidants to block the detrimental effects of ROS have produced mixed or negative results precipitating the interest in natural products. Blueberries are readily available product with the highest antioxidant capacity among fruits and vegetables. Methods and Results: Following 3-mo of BD or a regular control diet (CD), the threshold for mitochondrial permeability transition (tMPT) was measured in isolated cardiomyocytes obtained from young male Fischer-344 rats. Compared to CD, BD resulted in a 24% increase (pMPT. The remaining animals were subjected to a permanent ligation of the left descending coronary artery. 24 hrs later resulting myocardial infarction (MI) in rats on BD was 22% less than in CD rats (p

Original languageEnglish (US)
Article numbere5954
JournalPLoS One
Volume4
Issue number6
DOIs
StatePublished - Jun 18 2009
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Ahmet, I., Spangler, E., Shukitt-Hale, B., Juhaszova, M., Sollott, S. J., Joseph, J. A., Ingram, D. K., & Talan, M. (2009). Blueberry-enriched diet protects rat heart from ischemic damage. PLoS One, 4(6), [e5954]. https://doi.org/10.1371/journal.pone.0005954