Blueberry-enriched diet protects rat heart from ischemic damage

Ismayil Ahmet, Edward Spangler, Barbara Shukitt-Hale, Magdalena Juhaszova, Steven J. Sollott, James A. Joseph, Donald K. Ingram, Mark Talan

Research output: Contribution to journalArticle

Abstract

Objectives: To assess the cardioprotective properties of a blueberry enriched diet (BD). Background: Reactive oxygen species (ROS) play a major role in ischemia-related myocardial injury. The attempts to use synthetic antioxidants to block the detrimental effects of ROS have produced mixed or negative results precipitating the interest in natural products. Blueberries are readily available product with the highest antioxidant capacity among fruits and vegetables. Methods and Results: Following 3-mo of BD or a regular control diet (CD), the threshold for mitochondrial permeability transition (tMPT) was measured in isolated cardiomyocytes obtained from young male Fischer-344 rats. Compared to CD, BD resulted in a 24% increase (pMPT. The remaining animals were subjected to a permanent ligation of the left descending coronary artery. 24 hrs later resulting myocardial infarction (MI) in rats on BD was 22% less than in CD rats (p

Original languageEnglish (US)
Article numbere5954
JournalPLoS One
Volume4
Issue number6
DOIs
StatePublished - Jun 18 2009
Externally publishedYes

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Blueberry Plants
blueberries
Nutrition
Rats
heart
Diet
rats
diet
reactive oxygen species
Reactive Oxygen Species
Antioxidants
cardioprotective effect
antioxidants
myocardial infarction
Inbred F344 Rats
Vegetables
coronary vessels
ischemia
Fruits
Biological Products

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Ahmet, I., Spangler, E., Shukitt-Hale, B., Juhaszova, M., Sollott, S. J., Joseph, J. A., ... Talan, M. (2009). Blueberry-enriched diet protects rat heart from ischemic damage. PLoS One, 4(6), [e5954]. https://doi.org/10.1371/journal.pone.0005954

Blueberry-enriched diet protects rat heart from ischemic damage. / Ahmet, Ismayil; Spangler, Edward; Shukitt-Hale, Barbara; Juhaszova, Magdalena; Sollott, Steven J.; Joseph, James A.; Ingram, Donald K.; Talan, Mark.

In: PLoS One, Vol. 4, No. 6, e5954, 18.06.2009.

Research output: Contribution to journalArticle

Ahmet, I, Spangler, E, Shukitt-Hale, B, Juhaszova, M, Sollott, SJ, Joseph, JA, Ingram, DK & Talan, M 2009, 'Blueberry-enriched diet protects rat heart from ischemic damage', PLoS One, vol. 4, no. 6, e5954. https://doi.org/10.1371/journal.pone.0005954
Ahmet I, Spangler E, Shukitt-Hale B, Juhaszova M, Sollott SJ, Joseph JA et al. Blueberry-enriched diet protects rat heart from ischemic damage. PLoS One. 2009 Jun 18;4(6). e5954. https://doi.org/10.1371/journal.pone.0005954
Ahmet, Ismayil ; Spangler, Edward ; Shukitt-Hale, Barbara ; Juhaszova, Magdalena ; Sollott, Steven J. ; Joseph, James A. ; Ingram, Donald K. ; Talan, Mark. / Blueberry-enriched diet protects rat heart from ischemic damage. In: PLoS One. 2009 ; Vol. 4, No. 6.
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