Bloodplasma separation in Y-shaped bifurcating microfluidic channels: A dissipative particle dynamics simulation study

Xuejin Li, Aleksander S. Popel, George Em Karniadakis

Research output: Contribution to journalArticlepeer-review

Abstract

The motion of a suspension of red blood cells (RBCs) flowing in a Y-shaped bifurcating microfluidic channel is investigated using a validated low-dimensional RBC model based on dissipative particle dynamics. Specifically, the RBC is represented as a closed torus-like ring of ten colloidal particles, which leads to efficient simulations of blood flow in microcirculation over a wide range of hematocrits. Adaptive no-slip wall boundary conditions were implemented to model hydrodynamic flow within a specific wall structure of diverging three-dimensional microfluidic channels, paying attention to controlling density fluctuations. Plasma skimming and the all-or-nothing phenomenon of RBCs in a bifurcating microfluidic channel have been investigated in our simulations for healthy and diseased blood, including the size of a cell-free layer on the daughter branches. The feed hematocrit level in the parent channel has considerable influence on bloodplasma separation. Compared to the bloodplasma separation efficiencies of healthy RBCs, malaria-infected stiff RBCs (iRBCs) have a tendency to travel into the low flow-rate daughter branch because of their different initial distribution in the parent channel. Our simulation results are consistent with previously published experimental results and theoretical predictions.

Original languageEnglish (US)
Article number026010
JournalPhysical biology
Volume9
Issue number2
DOIs
StatePublished - Apr 2012

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Molecular Biology
  • Cell Biology

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