Blood–Brain Glucose Transport in the Conscious Rat: Comparison of the Intravenous and Intracarotid Injection Methods

Albert Gjedde, Mette Rasmussen

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract: The unidirectional transfer of d‐glucose from blood to parietal cortex tissue of the brain of awake rats was measured by single intravenous injection of tracer glucose, as well as by single intracarotid injection according to the method of Oldendorf. The maximal unidirectional blood–brain glucose transfer rate (Tmax) was 407 μ mol (100 g)–1 min–1 when measured by intravenous injection, and 352 μ mol (100 g)–1 min–1 when measured by intracarotid injection. The half–saturation constants (Km) were 7.8 mm and 16.8 HIM, respectively. The comparison shows that the two methods give similar results when cerebral perfusion is assessed accurately.

Original languageEnglish (US)
Pages (from-to)1375-1381
Number of pages7
JournalJournal of Neurochemistry
Volume35
Issue number6
DOIs
StatePublished - Dec 1980

Keywords

  • Blood‐brain barrier
  • Blood‐brain glucose transfer

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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