Blood‐Brain Glucose Transfer in Spreading Depression

Albert Gjedde, Anker Jón Hansen, Bjørn Quistorff

Research output: Contribution to journalArticlepeer-review


Abstract Spreading depression in rat brain cortex is associated with a twofold increase of cerebral blood flow. It is not known whether this increase is coupled to increases of cerebral metabolic rate and glucose transport from blood to brain. During the passage of a single spreading depression, we measured blood‐brain glucose transport and glucose metabolism in rat cerebral cortex by single intravenous injection of tracer glucose. Blood flow and tissue content of glucose were measured as well. Reduction of tissue glucose and the consequent increase of net transfer of glucose from blood to brain were consistent with a threefold increase of the consumption of glucose before the increase of blood flow. There was no increase of unidirectional blood‐brain transfer.

Original languageEnglish (US)
Pages (from-to)807-812
Number of pages6
JournalJournal of Neurochemistry
Issue number4
StatePublished - Oct 1981


  • Glucose transport
  • Spreading depression
  • cerebral blood flow

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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