Blood vessels as a source of progenitor cells in human embryonic and adult life

M. Crisan, B. Zheng, E. Zambidis, S. Yap, M. Tavian, B. Sun, J. P. Giacobino, L. Casteilla, J. Huard, B. Péault

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Recent experimental results in culture and in vivo are summarized that show the existence of developmental relationships between cells that build up blood vessel walls and some previously unrelated tissues and organs. It was formerly demonstrated, in lower vertebrates as well as mammals, including humans, that discrete subsets of blood-forming endothelial cells play a key role in the emergence of the definitive hematopoietic system. We have also documented the existence in human skeletal muscle of endothelium-borne, extremely potent myogenic progenitor cells. Finally, we have characterized and purified perivascular cells - or pericytes - from human tissues and demonstrated their ability to give rise to mesodermal differentiated derivatives, principally skeletal muscle.

Original languageEnglish (US)
Title of host publicationStem Cells and their Potential for Clinical Application
PublisherSpringer Verlag
Pages137-147
Number of pages11
ISBN (Print)9781402064678
DOIs
StatePublished - 2008

Publication series

NameNATO Security through Science Series C: Environmental Security
ISSN (Print)1871-4668

Keywords

  • Blood vessel
  • Endothelial cell
  • Pericyte
  • Skeletal muscle
  • Stem cell

ASJC Scopus subject areas

  • Environmental Science(all)

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