TY - JOUR
T1 - Blood utilization and clinical outcomes in pancreatic surgery before and after implementation of patient blood management
AU - Frank, Steven M.
AU - Lo, Brian D.
AU - Yesantharao, Lekha V.
AU - Merkel, Kevin R.
AU - Qin, Caroline X.
AU - Cho, Brian C.
AU - Lee, K. H.Ken
AU - Wintermeyer, Tyler L.
AU - Hebbar, Sachidanand
AU - Burkhart, Richard A.
AU - Goel, Ruchika
AU - Gehrie, Eric A.
N1 - Funding Information:
The authors would like to acknowledge both financial and project management support from The Johns Hopkins Health System Armstrong Institute for Patient Safety and Quality, Baltimore, Maryland.
Publisher Copyright:
© 2020 AABB
PY - 2020/11
Y1 - 2020/11
N2 - Background: Over the past decade, patient blood management (PBM) programs have been developed to reduce allogeneic blood utilization. This is particularly important in pancreatic surgery, which has historically been associated with high transfusion requirements and morbid event rates. This study investigated blood utilization and clinical outcomes in pancreatic surgery before, during, and after the implementation of PBM. Study Design and Methods: A total of 3482 pancreatic surgery patients were assessed in a 10-year retrospective cohort study (2009-2019) at a single academic center. Baseline patient characteristics, transfusion practices, postoperative morbidity (infectious, thrombotic, ischemic, respiratory, and renal complications), mortality, and length of stay were compared between patients in the pre-PBM (2009-2013), early-PBM (2014-2016), and mature-PBM (2017-2019) time periods. Multivariable analysis assessed the odds for composite morbidity/mortality. Results: Comparing the mature-PBM to pre-PBM cohorts, transfused units per 100 discharged patients decreased by 53% for erythrocytes (155 to 73; P <.0001), 81% for plasma (79 to 15; P <.038), and 75% for platelets (10 to 2.5; P <.005). Clinical outcomes improved as well, with composite morbid event rates decreasing by more than 50%, from 236 in 1438 patients (16.4%) to 85 in 1145 patients (7.4%) (P <.0001). Mortality and length of stay remained unchanged. Compared to the pre-PBM time period, early-PBM was associated with a risk-adjusted decrease in composite morbidity/mortality (OR 0.73; 95% CI 0.57-0.93; P =.010), while mature-PBM demonstrated a further incremental decrease (OR 0.44; 95% CI 0.33-0.57; P <.0001). Conclusions: The implementation of PBM was associated with substantially decreased blood utilization in pancreatic surgery, without negatively impacting clinical outcomes.
AB - Background: Over the past decade, patient blood management (PBM) programs have been developed to reduce allogeneic blood utilization. This is particularly important in pancreatic surgery, which has historically been associated with high transfusion requirements and morbid event rates. This study investigated blood utilization and clinical outcomes in pancreatic surgery before, during, and after the implementation of PBM. Study Design and Methods: A total of 3482 pancreatic surgery patients were assessed in a 10-year retrospective cohort study (2009-2019) at a single academic center. Baseline patient characteristics, transfusion practices, postoperative morbidity (infectious, thrombotic, ischemic, respiratory, and renal complications), mortality, and length of stay were compared between patients in the pre-PBM (2009-2013), early-PBM (2014-2016), and mature-PBM (2017-2019) time periods. Multivariable analysis assessed the odds for composite morbidity/mortality. Results: Comparing the mature-PBM to pre-PBM cohorts, transfused units per 100 discharged patients decreased by 53% for erythrocytes (155 to 73; P <.0001), 81% for plasma (79 to 15; P <.038), and 75% for platelets (10 to 2.5; P <.005). Clinical outcomes improved as well, with composite morbid event rates decreasing by more than 50%, from 236 in 1438 patients (16.4%) to 85 in 1145 patients (7.4%) (P <.0001). Mortality and length of stay remained unchanged. Compared to the pre-PBM time period, early-PBM was associated with a risk-adjusted decrease in composite morbidity/mortality (OR 0.73; 95% CI 0.57-0.93; P =.010), while mature-PBM demonstrated a further incremental decrease (OR 0.44; 95% CI 0.33-0.57; P <.0001). Conclusions: The implementation of PBM was associated with substantially decreased blood utilization in pancreatic surgery, without negatively impacting clinical outcomes.
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U2 - 10.1111/trf.16063
DO - 10.1111/trf.16063
M3 - Article
C2 - 32897635
AN - SCOPUS:85090455660
SN - 0041-1132
VL - 60
SP - 2581
EP - 2590
JO - Transfusion
JF - Transfusion
IS - 11
ER -