TY - JOUR
T1 - Blood supply and vascular reactivity of the spinal cord under normal and pathological conditions
T2 - A review
AU - Martirosyan, Nikolay L.
AU - Feuerstein, Jeann E.S.
AU - Theodore, Nicholas
AU - Cavalcanti, Daniel D.
AU - Spetzler, Robert F.
AU - Preul, Mark C.
PY - 2011/9
Y1 - 2011/9
N2 - The authors present a review of spinal cord blood supply, discussing the anatomy of the vascular system and physiological aspects of blood flow regulation in normal and injured spinal cords. Unique anatomical functional properties of vessels and blood supply determine the susceptibility of the spinal cord to damage, especially ischemia. Spinal cord injury (SCI), for example, complicating thoracoabdominal aortic aneurysm repair is associated with ischemic trauma. The rate of this devastating complication has been decreased significantly by instituting physiological methods of protection. Traumatic SCI causes complex changes in spinal cord blood flow, which are closely related to the severity of injury. Manipulating physiological parameters such as mean arterial blood pressure and intrathecal pressure may be beneficial for patients with an SCI. Studying the physiopathological processes of the spinal cord under vascular compromise remains challenging because of its central role in almost all of the body's hemodynamic and neurofunctional processes.
AB - The authors present a review of spinal cord blood supply, discussing the anatomy of the vascular system and physiological aspects of blood flow regulation in normal and injured spinal cords. Unique anatomical functional properties of vessels and blood supply determine the susceptibility of the spinal cord to damage, especially ischemia. Spinal cord injury (SCI), for example, complicating thoracoabdominal aortic aneurysm repair is associated with ischemic trauma. The rate of this devastating complication has been decreased significantly by instituting physiological methods of protection. Traumatic SCI causes complex changes in spinal cord blood flow, which are closely related to the severity of injury. Manipulating physiological parameters such as mean arterial blood pressure and intrathecal pressure may be beneficial for patients with an SCI. Studying the physiopathological processes of the spinal cord under vascular compromise remains challenging because of its central role in almost all of the body's hemodynamic and neurofunctional processes.
KW - Autoregulation
KW - Spinal cord blood supply
KW - Spinal cord injury
KW - Vascular disorders
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U2 - 10.3171/2011.4.SPINE10543
DO - 10.3171/2011.4.SPINE10543
M3 - Review article
C2 - 21663407
AN - SCOPUS:80052584989
SN - 1547-5654
VL - 15
SP - 238
EP - 251
JO - Journal of Neurosurgery: Spine
JF - Journal of Neurosurgery: Spine
IS - 3
ER -