Blood pressure genomics

Georg B. Ehret

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Blood pressure genetics has been instrumental in understanding the pathways that regulate blood pressure and induce hypertension. Two types of approaches have been used with great success: First, studies of hypertensive families in which monogenic blood pressure elevation can be explained by mutations in one of a dozen genes identified so far. Unfortunately, the relevance of these rare familial variants is limited when predicting primary hypertension in the general population. Second, association meta-analyses based on genome-wide genotyping using large sample sizes that have so far yielded about around 60 common genetic variants predicting blood pressure with a small, but reproducible, impact on blood pressure in the general population. This chapter summarizes the current findings based on genome-wide association studies and outlines the conclusions that can be drawn when considering the variants identified in aggregate and gives an outlook of the challenges ahead.

Original languageEnglish (US)
Title of host publicationPathophysiology and Pharmacotherapy of Cardiovascular Disease
PublisherSpringer International Publishing
Pages685-694
Number of pages10
ISBN (Electronic)9783319159614
ISBN (Print)9783319159607
DOIs
StatePublished - Jan 1 2015

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Keywords

  • Blood pressure
  • Cardiovascular risk factors
  • Complex trait genetics
  • Genome-wide association studies
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Ehret, G. B. (2015). Blood pressure genomics. In Pathophysiology and Pharmacotherapy of Cardiovascular Disease (pp. 685-694). Springer International Publishing. https://doi.org/10.1007/978-3-319-15961-4_32