Blood pressure augmentation in acute ischemic stroke

Robert J. Wityk

Research output: Contribution to journalArticle

Abstract

Although control of hypertension is established as an important factor in the primary and secondary prevention of stroke, management of blood pressure in the setting of acute ischemic stroke remains controversial. Given limited data, the general consensus is that there is no proven benefit to lowering blood pressure in the first hours to days after acute ischemic stroke. Instead, there is concern that relative hypotension may lead to worsening of cerebral ischemia. For many years, the use of blood pressure augmentation ("induced hypertension") has been studied in animal models and in humans as a means of maintaining or improving perfusion to ischemic brain tissue. This approach is now widely used in neurocritical care units to treat delayed neurological deficits after subarachnoid hemorrhage, but its use in ischemic stroke patients remains anecdotal. This article reviews the cerebral physiology, animal models and human studies of induced hypertension as a treatment for acute ischemic stroke. Although there has not been a large, randomized clinical trial of this treatment, the available clinical data suggests that induced hypertension can result in at least short-term neurological improvement, with an acceptable degree of safety.

Original languageEnglish (US)
Pages (from-to)63-73
Number of pages11
JournalJournal of the Neurological Sciences
Volume261
Issue number1-2
DOIs
StatePublished - Oct 15 2007

Fingerprint

Stroke
Blood Pressure
Hypertension
Animal Models
Subarachnoid Hemorrhage
Primary Prevention
Secondary Prevention
Brain Ischemia
Hypotension
Randomized Controlled Trials
Perfusion
Safety
Brain
Therapeutics

Keywords

  • Acute ischemic stroke
  • Blood pressure
  • Induced hypertension
  • Ischemic penumbra
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Blood pressure augmentation in acute ischemic stroke. / Wityk, Robert J.

In: Journal of the Neurological Sciences, Vol. 261, No. 1-2, 15.10.2007, p. 63-73.

Research output: Contribution to journalArticle

Wityk, Robert J. / Blood pressure augmentation in acute ischemic stroke. In: Journal of the Neurological Sciences. 2007 ; Vol. 261, No. 1-2. pp. 63-73.
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