Blood oxygenation dependence of t1 and t2 in the isolated, perfused rabbit heart at 4.7t

Michael K. Atalay, Scott B. Reeder, Elias Zerhouni, John R. Forder

Research output: Contribution to journalArticle

Abstract

An MR line scan protocol has been used to measure relaxation parameters (T1 and T2) in isolated, blood perfused rabbit hearts at various blood oxygenations. Hearts were retro‐gradely perfused at 37°C with a cardioplegic solution (modified St. Thomas' solution) containing sheep red blood cells and adenosine (1 mM) to maximally vasodilate the coronary vascular bed. Arresting the hearts eliminated motion complications and minimized arteriovenous oxygenation differences. The authors have found that under conditions of stable flow, there is a strong correlation between T2 in myocardial septa and hemoglobin (Hb) saturation, while tissue T1 is virtually independent of blood oxygenation. These effects are believed to be due to the paramagnetic agent deoxyhemoglobin.

Original languageEnglish (US)
Pages (from-to)623-627
Number of pages5
JournalMagnetic Resonance in Medicine
Volume34
Issue number4
DOIs
StatePublished - 1995

Fingerprint

Rabbits
Cardioplegic Solutions
Adenosine
Blood Vessels
Sheep
Hemoglobins
Erythrocytes
Thomas' solution
deoxyhemoglobin

Keywords

  • functional MRI
  • myocardial imaging
  • myocardial oxygen content

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Blood oxygenation dependence of t1 and t2 in the isolated, perfused rabbit heart at 4.7t. / Atalay, Michael K.; Reeder, Scott B.; Zerhouni, Elias; Forder, John R.

In: Magnetic Resonance in Medicine, Vol. 34, No. 4, 1995, p. 623-627.

Research output: Contribution to journalArticle

Atalay, Michael K. ; Reeder, Scott B. ; Zerhouni, Elias ; Forder, John R. / Blood oxygenation dependence of t1 and t2 in the isolated, perfused rabbit heart at 4.7t. In: Magnetic Resonance in Medicine. 1995 ; Vol. 34, No. 4. pp. 623-627.
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