Blood group, immunity, and risk of infection with Vibrio cholerae in an area of endemicity

Jason B. Harris, Ashraful I. Khan, Regina C. LaRocque, David J. Dorer, Fahima Chowdhury, Abu S G Faruque, David A. Sack, Edward T. Ryan, Firdausi Qadri, Stephen B. Calderwood

Research output: Contribution to journalArticle

Abstract

Individuals with blood group O are more susceptible than other individuals to severe cholera, although the mechanism underlying this association is unknown. To assess the respective roles of both intrinsic host factors and adaptive immune responses that might influence susceptibility to infection with Vibrio cholerae, we prospectively followed a cohort of household contacts of patients with cholera in Bangladesh. In this study, we made the novel observation that persons with blood group O were less likely than those with other blood groups to become infected with V. cholerae O1 (odds ratio [OR], 0.67; 95% confidence interval [CI], 0.53 to 0.85; P = 0.008). Consistent with prior studies, however, household contacts with blood group O were more likely to develop severe illness if infected with V. cholerae O1 (OR, 2.3; 95% CI, 0.98 to 5.59; P = 0.05). While blood group O protected significantly against infection with V. cholerae O1, there was no evidence of protection against V. cholerae O139. A multivariate analysis demonstrated that the association between blood group O and protection from infection with V. cholerae O1 was independent of age, gender, and baseline anti-cholera toxin and vibriocidal antibody titers. Based on this epidemiologic evidence, we propose a hypothesis for understanding the association between blood group O and the risk of infection with V. cholerae O1 and O139 as well as the risk of developing severe symptoms once infected.

Original languageEnglish (US)
Pages (from-to)7422-7427
Number of pages6
JournalInfection and Immunity
Volume73
Issue number11
DOIs
StatePublished - Nov 2005
Externally publishedYes

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Vibrio cholerae
Blood Group Antigens
Vibrio cholerae O1
Immunity
Infection
Vibrio cholerae O139
Cholera
Odds Ratio
Confidence Intervals
Intrinsic Factor
Bangladesh
Cholera Toxin
Adaptive Immunity
Multivariate Analysis
Observation
Antibodies

ASJC Scopus subject areas

  • Immunology

Cite this

Harris, J. B., Khan, A. I., LaRocque, R. C., Dorer, D. J., Chowdhury, F., Faruque, A. S. G., ... Calderwood, S. B. (2005). Blood group, immunity, and risk of infection with Vibrio cholerae in an area of endemicity. Infection and Immunity, 73(11), 7422-7427. https://doi.org/10.1128/IAI.73.11.7422-7427.2005

Blood group, immunity, and risk of infection with Vibrio cholerae in an area of endemicity. / Harris, Jason B.; Khan, Ashraful I.; LaRocque, Regina C.; Dorer, David J.; Chowdhury, Fahima; Faruque, Abu S G; Sack, David A.; Ryan, Edward T.; Qadri, Firdausi; Calderwood, Stephen B.

In: Infection and Immunity, Vol. 73, No. 11, 11.2005, p. 7422-7427.

Research output: Contribution to journalArticle

Harris, JB, Khan, AI, LaRocque, RC, Dorer, DJ, Chowdhury, F, Faruque, ASG, Sack, DA, Ryan, ET, Qadri, F & Calderwood, SB 2005, 'Blood group, immunity, and risk of infection with Vibrio cholerae in an area of endemicity', Infection and Immunity, vol. 73, no. 11, pp. 7422-7427. https://doi.org/10.1128/IAI.73.11.7422-7427.2005
Harris, Jason B. ; Khan, Ashraful I. ; LaRocque, Regina C. ; Dorer, David J. ; Chowdhury, Fahima ; Faruque, Abu S G ; Sack, David A. ; Ryan, Edward T. ; Qadri, Firdausi ; Calderwood, Stephen B. / Blood group, immunity, and risk of infection with Vibrio cholerae in an area of endemicity. In: Infection and Immunity. 2005 ; Vol. 73, No. 11. pp. 7422-7427.
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