Blood gas and acid-base balance during cardiopulmonary resuscitation by intrathroacic and abdominal pressure variations

R. Beyar, Y. Kishon, E. Kimmel, S. Sideman, U. Dinnar

Research output: Contribution to journalArticle

Abstract

The blood gases and acid-base balance in a modified cardiopulmonary resuscitation (CPR) technique, based on intrathoracic and abdominal pressure variations by means of circumferential chest and abdominal balloon inflation, were examined in seven mongrel dogs. CPR proceeded for pcriods lasting 30 min or more and was monitored by measurements of aortic and right ventricular pressures and carotid blood flow during the compression (artificial systole) and the relaxation phase (artificial diastole). The carotid blood flow was 21.7±7.8 (mean±SD) ml/min, which was 0.18±0.6 (mean±SD) of the baseline mean carotid flow. Arterial blood was well oxygenated throughout the experiments, and low PCO2 levels (5-9 mm Hg) caused an initial severe alkalosis (pH=7.94). However, a gradual decline in the pH was observed, reaching a value of 7.34±0.11 in the arterial blood after 30 min of CPR. The venous blood had a very low oxygen content (less than 25.5%) with a low PO2 and a normal PCO2 (43.7±7.3 mm Hg) throughout the experiment. A gradually developing metabolic acidosis was reflected in the pH values, and an increase in base deficit from 2.25±5.6 meq/1 prior to CPR to 16.7±3.2 meq/1 after 30 min of CPR was observed. High arteriovenous differences in oxygen content (greater than 66.4%) and CO2 tension (30.1-41.5 mm Hg) with a slowly developing metabolic acidosis were noted. Thus, CPR by thoracic and abdominal pressure variations is associated with a slowly developing metabolic acidosis which is the result of the combination of hyperventilation and a low perfusion state.

Original languageEnglish (US)
Pages (from-to)326-333
Number of pages8
JournalBasic Research in Cardiology
Volume81
Issue number3
DOIs
StatePublished - May 1986
Externally publishedYes

Fingerprint

Acid-Base Equilibrium
Cardiopulmonary Resuscitation
Gases
Pressure
Acidosis
Thorax
Oxygen
Alkalosis
Diastole
Hyperventilation
Systole
Economic Inflation
Ventricular Pressure
Perfusion
Dogs

Keywords

  • acid-base
  • blood gases
  • cardiopulmonary resuscitation
  • thoracic pressure variations

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Blood gas and acid-base balance during cardiopulmonary resuscitation by intrathroacic and abdominal pressure variations. / Beyar, R.; Kishon, Y.; Kimmel, E.; Sideman, S.; Dinnar, U.

In: Basic Research in Cardiology, Vol. 81, No. 3, 05.1986, p. 326-333.

Research output: Contribution to journalArticle

Beyar, R. ; Kishon, Y. ; Kimmel, E. ; Sideman, S. ; Dinnar, U. / Blood gas and acid-base balance during cardiopulmonary resuscitation by intrathroacic and abdominal pressure variations. In: Basic Research in Cardiology. 1986 ; Vol. 81, No. 3. pp. 326-333.
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abstract = "The blood gases and acid-base balance in a modified cardiopulmonary resuscitation (CPR) technique, based on intrathoracic and abdominal pressure variations by means of circumferential chest and abdominal balloon inflation, were examined in seven mongrel dogs. CPR proceeded for pcriods lasting 30 min or more and was monitored by measurements of aortic and right ventricular pressures and carotid blood flow during the compression (artificial systole) and the relaxation phase (artificial diastole). The carotid blood flow was 21.7±7.8 (mean±SD) ml/min, which was 0.18±0.6 (mean±SD) of the baseline mean carotid flow. Arterial blood was well oxygenated throughout the experiments, and low PCO2 levels (5-9 mm Hg) caused an initial severe alkalosis (pH=7.94). However, a gradual decline in the pH was observed, reaching a value of 7.34±0.11 in the arterial blood after 30 min of CPR. The venous blood had a very low oxygen content (less than 25.5{\%}) with a low PO2 and a normal PCO2 (43.7±7.3 mm Hg) throughout the experiment. A gradually developing metabolic acidosis was reflected in the pH values, and an increase in base deficit from 2.25±5.6 meq/1 prior to CPR to 16.7±3.2 meq/1 after 30 min of CPR was observed. High arteriovenous differences in oxygen content (greater than 66.4{\%}) and CO2 tension (30.1-41.5 mm Hg) with a slowly developing metabolic acidosis were noted. Thus, CPR by thoracic and abdominal pressure variations is associated with a slowly developing metabolic acidosis which is the result of the combination of hyperventilation and a low perfusion state.",
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