Blood eosinophils and treatment response in hospitalized exacerbations of chronic obstructive pulmonary disease

A case-control study

Laura Serafino-Agrusa, Nicola Scichilone, Mario Spatafora, Salvatore Battaglia

Research output: Contribution to journalArticle

Abstract

Background: In outpatients with chronic obstructive pulmonary disease (COPD), blood eosinophilia is considered as a biomarker of response to systemic corticosteroid therapy. However, little is known on whether blood eosinophilia is also predictive of positive clinical outcome in severe acute exacerbations of COPD requiring hospitalization. We hypothesized that blood eosinophil-positive severe acute exacerbations of COPD differ from eosinophil-negative ones in terms of response to therapy and clinical outcomes. Methods: To test our experimental hypothesis, we retrospectively analyzed medical records of patients with COPD admitted to our ward because of severe exacerbation, over a two-year period of observation. After evaluation of inclusion and exclusion criteria, 132 patients were selected and divided in cases (blood eosinophilia ≥2% at admission; n = 20) and controls (blood eosinophilia

Original languageEnglish (US)
Pages (from-to)89-94
Number of pages6
JournalPulmonary Pharmacology and Therapeutics
Volume37
DOIs
StatePublished - Apr 1 2016
Externally publishedYes

Fingerprint

Pulmonary diseases
Eosinophils
Chronic Obstructive Pulmonary Disease
Case-Control Studies
Eosinophilia
Blood
Therapeutics
Biomarkers
Medical Records
Adrenal Cortex Hormones
Hospitalization
Outpatients
Observation

Keywords

  • Biological markers/blood
  • COPD
  • Eosinophils
  • Glucocorticoids/administration & dosage
  • Length of stay

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pharmacology (medical)
  • Biochemistry, medical

Cite this

Blood eosinophils and treatment response in hospitalized exacerbations of chronic obstructive pulmonary disease : A case-control study. / Serafino-Agrusa, Laura; Scichilone, Nicola; Spatafora, Mario; Battaglia, Salvatore.

In: Pulmonary Pharmacology and Therapeutics, Vol. 37, 01.04.2016, p. 89-94.

Research output: Contribution to journalArticle

Serafino-Agrusa, Laura ; Scichilone, Nicola ; Spatafora, Mario ; Battaglia, Salvatore. / Blood eosinophils and treatment response in hospitalized exacerbations of chronic obstructive pulmonary disease : A case-control study. In: Pulmonary Pharmacology and Therapeutics. 2016 ; Vol. 37. pp. 89-94.
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