Abstract
We examined leukocyte counts and ex vivo cytokine response of whole blood to lipopolysaccharide (LPS) or lipoteichoic acid (LTA) in patients under low-dose molgramostim therapy. Patients were injected subcutaneously daily for ten days with 1 μg/kg (n =9) or 2 μg/kg (n = 14) molgramostim. Leukocytosis was observed in all patients, but only the eosinophil fraction was significantly increased in relation to other leukocyte populations. Ex vivo IFN-γ release was decreased and IL-10 and IL-1ra secretion were increased in response to LPS or LTA. Thus, in non-neutropenic patients, leukocytosis can already be initiated by Bow doses of molgramostim. The ex vivo cytokine data suggest that these doses prime blood towards a systemic anti-inflammatory response. (C) 2000 Academic Press.
Original language | English (US) |
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Pages (from-to) | 1570-1574 |
Number of pages | 5 |
Journal | Cytokine |
Volume | 12 |
Issue number | 10 |
DOIs | |
State | Published - 2000 |
Externally published | Yes |
Keywords
- Blood
- Cytokines
- Growth factors
- Human
- Inflammation
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Biochemistry
- Hematology
- Molecular Biology