Abstract
Diabetic patients with increased plasma glucose concentrations may develop cerebral symptoms of hypoglycemia when their plasma glucose is rapidly lowered to normal concentrations. The symptoms may indicate insufficient transport of glucose from blood to brain. In rats with chronic hyperglycemia the maximum glucose transport capacity of the blood-brain barrier decreased from 400 to 290 micromoles per 100 grams per minute. When plasma glucose was lowered to normal values, the glucose transport rate into brain was 20 percent below normal. This suggests that repressive changes of the glucose transport mechanism occur in brain endothelial cells in response to increased plasma glucose.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 456-457 |
| Number of pages | 2 |
| Journal | Science |
| Volume | 214 |
| Issue number | 4519 |
| State | Published - 1981 |
| Externally published | Yes |
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ASJC Scopus subject areas
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Cite this
Blood-brain glucose transfer : Repression in chronic hyperglycemia. / Gjedde, Albert; Crone, Christian.
In: Science, Vol. 214, No. 4519, 1981, p. 456-457.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Blood-brain glucose transfer
T2 - Repression in chronic hyperglycemia
AU - Gjedde, Albert
AU - Crone, Christian
PY - 1981
Y1 - 1981
N2 - Diabetic patients with increased plasma glucose concentrations may develop cerebral symptoms of hypoglycemia when their plasma glucose is rapidly lowered to normal concentrations. The symptoms may indicate insufficient transport of glucose from blood to brain. In rats with chronic hyperglycemia the maximum glucose transport capacity of the blood-brain barrier decreased from 400 to 290 micromoles per 100 grams per minute. When plasma glucose was lowered to normal values, the glucose transport rate into brain was 20 percent below normal. This suggests that repressive changes of the glucose transport mechanism occur in brain endothelial cells in response to increased plasma glucose.
AB - Diabetic patients with increased plasma glucose concentrations may develop cerebral symptoms of hypoglycemia when their plasma glucose is rapidly lowered to normal concentrations. The symptoms may indicate insufficient transport of glucose from blood to brain. In rats with chronic hyperglycemia the maximum glucose transport capacity of the blood-brain barrier decreased from 400 to 290 micromoles per 100 grams per minute. When plasma glucose was lowered to normal values, the glucose transport rate into brain was 20 percent below normal. This suggests that repressive changes of the glucose transport mechanism occur in brain endothelial cells in response to increased plasma glucose.
UR - http://www.scopus.com/inward/record.url?scp=0019787087&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019787087&partnerID=8YFLogxK
M3 - Article
C2 - 7027439
AN - SCOPUS:0019787087
VL - 214
SP - 456
EP - 457
JO - Science
JF - Science
SN - 0036-8075
IS - 4519
ER -