Blood-brain barrier permeability to the neuroprotectant oxyresveratrol

Christian Breuer; Gerald Wolf; Shaida A. Andrabi; Peter Lorenz; Thomas F.W. Horn

doi:10.1016/j.neulet.2005.09.081

Blood-brain barrier permeability to the neuroprotectant oxyresveratrol

Christian Breuer, Gerald Wolf, Shaida A. Andrabi, Peter Lorenz, Thomas F.W. Horn

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

We investigated to what extent the antioxidative hydroxystilbene oxyresveratrol (trans-2,3′,4,5′-tetrahydroxystilbene, OXY), that we showed earlier to be strongly neuroprotective in a stroke model, may cross the blood-brain barrier (BBB) in healthy rats and in subjects submitted to focal infarction. Tissue extraction and in vivo microdialysis in the striatum show that systematically applied OXY is able to penetrate the BBB in control animals, but to a low extent. Microdialysis samples from animals that were subjected to a middle cerebral artery occlusion (MCAO) displayed strongly increased OXY levels (more than six-fold) in the infarct region as compared to sham-operated rats. Our data show that OXY may exert direct protective effects in the brain by crossing the BBB and may prove an excellent complementary drug for the treatment of neurodegenerative disorders that causally involve oxidative/nitrosative stress, especially in stroke.

Original language	English (US)
Pages (from-to)	113-118
Number of pages	6
Journal	Neuroscience Letters
Volume	393
Issue number	2-3
DOIs	https://doi.org/10.1016/j.neulet.2005.09.081
State	Published - Jan 30 2006
Externally published	Yes

Keywords

Hydroxystilbenes
Ischemia
MCAO
Microdialysis
Neuroprotection
Stroke

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2005.09.081

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title = "Blood-brain barrier permeability to the neuroprotectant oxyresveratrol",

abstract = "We investigated to what extent the antioxidative hydroxystilbene oxyresveratrol (trans-2,3′,4,5′-tetrahydroxystilbene, OXY), that we showed earlier to be strongly neuroprotective in a stroke model, may cross the blood-brain barrier (BBB) in healthy rats and in subjects submitted to focal infarction. Tissue extraction and in vivo microdialysis in the striatum show that systematically applied OXY is able to penetrate the BBB in control animals, but to a low extent. Microdialysis samples from animals that were subjected to a middle cerebral artery occlusion (MCAO) displayed strongly increased OXY levels (more than six-fold) in the infarct region as compared to sham-operated rats. Our data show that OXY may exert direct protective effects in the brain by crossing the BBB and may prove an excellent complementary drug for the treatment of neurodegenerative disorders that causally involve oxidative/nitrosative stress, especially in stroke.",

keywords = "Hydroxystilbenes, Ischemia, MCAO, Microdialysis, Neuroprotection, Stroke",

author = "Christian Breuer and Gerald Wolf and Andrabi, {Shaida A.} and Peter Lorenz and Horn, {Thomas F.W.}",

note = "Funding Information: FJ-C was a generous gift of L. Schmued [19] . The study was financially supported by the grant of the Kultus-Ministerium of the Land Sachsen-Anhalt (3T213/0703M).",

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doi = "10.1016/j.neulet.2005.09.081",

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AU - Breuer, Christian

AU - Wolf, Gerald

AU - Andrabi, Shaida A.

AU - Lorenz, Peter

AU - Horn, Thomas F.W.

N1 - Funding Information: FJ-C was a generous gift of L. Schmued [19] . The study was financially supported by the grant of the Kultus-Ministerium of the Land Sachsen-Anhalt (3T213/0703M).

PY - 2006/1/30

Y1 - 2006/1/30

N2 - We investigated to what extent the antioxidative hydroxystilbene oxyresveratrol (trans-2,3′,4,5′-tetrahydroxystilbene, OXY), that we showed earlier to be strongly neuroprotective in a stroke model, may cross the blood-brain barrier (BBB) in healthy rats and in subjects submitted to focal infarction. Tissue extraction and in vivo microdialysis in the striatum show that systematically applied OXY is able to penetrate the BBB in control animals, but to a low extent. Microdialysis samples from animals that were subjected to a middle cerebral artery occlusion (MCAO) displayed strongly increased OXY levels (more than six-fold) in the infarct region as compared to sham-operated rats. Our data show that OXY may exert direct protective effects in the brain by crossing the BBB and may prove an excellent complementary drug for the treatment of neurodegenerative disorders that causally involve oxidative/nitrosative stress, especially in stroke.

AB - We investigated to what extent the antioxidative hydroxystilbene oxyresveratrol (trans-2,3′,4,5′-tetrahydroxystilbene, OXY), that we showed earlier to be strongly neuroprotective in a stroke model, may cross the blood-brain barrier (BBB) in healthy rats and in subjects submitted to focal infarction. Tissue extraction and in vivo microdialysis in the striatum show that systematically applied OXY is able to penetrate the BBB in control animals, but to a low extent. Microdialysis samples from animals that were subjected to a middle cerebral artery occlusion (MCAO) displayed strongly increased OXY levels (more than six-fold) in the infarct region as compared to sham-operated rats. Our data show that OXY may exert direct protective effects in the brain by crossing the BBB and may prove an excellent complementary drug for the treatment of neurodegenerative disorders that causally involve oxidative/nitrosative stress, especially in stroke.

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KW - Stroke

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Blood-brain barrier permeability to the neuroprotectant oxyresveratrol

Abstract

Keywords

ASJC Scopus subject areas

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