Blood-brain barrier permeability to the neuroprotectant oxyresveratrol

Christian Breuer, Gerald Wolf, Shaida A. Andrabi, Peter Lorenz, Thomas F.W. Horn

Research output: Contribution to journalArticle

Abstract

We investigated to what extent the antioxidative hydroxystilbene oxyresveratrol (trans-2,3′,4,5′-tetrahydroxystilbene, OXY), that we showed earlier to be strongly neuroprotective in a stroke model, may cross the blood-brain barrier (BBB) in healthy rats and in subjects submitted to focal infarction. Tissue extraction and in vivo microdialysis in the striatum show that systematically applied OXY is able to penetrate the BBB in control animals, but to a low extent. Microdialysis samples from animals that were subjected to a middle cerebral artery occlusion (MCAO) displayed strongly increased OXY levels (more than six-fold) in the infarct region as compared to sham-operated rats. Our data show that OXY may exert direct protective effects in the brain by crossing the BBB and may prove an excellent complementary drug for the treatment of neurodegenerative disorders that causally involve oxidative/nitrosative stress, especially in stroke.

Original languageEnglish (US)
Pages (from-to)113-118
Number of pages6
JournalNeuroscience Letters
Volume393
Issue number2-3
DOIs
StatePublished - Jan 30 2006

Keywords

  • Hydroxystilbenes
  • Ischemia
  • MCAO
  • Microdialysis
  • Neuroprotection
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Breuer, C., Wolf, G., Andrabi, S. A., Lorenz, P., & Horn, T. F. W. (2006). Blood-brain barrier permeability to the neuroprotectant oxyresveratrol. Neuroscience Letters, 393(2-3), 113-118. https://doi.org/10.1016/j.neulet.2005.09.081