Abstract
Purpose of review The rapid progress in biomarker science is on the threshold of significantly changing clinical care for infants in the neonatal ICU. Infants with neonatal brain injuries will likely be the first group whose management is dramatically altered with point-of-care, rapidly available brain biomarker analysis. Providing an interim update on progress in this area is the purpose of this review. Recent findings Highlighted findings from the past 18 months of publications on biomarkers in neonatal brain injury include; Specific nonbrain markers of cardiac health and global asphyxia continue to provide information on brain injury after hypoxic-ischemic encephalopathy (HIE). Prediction of injury in the piglet hypoxia-ischemia model is improved with the use of a combination score of plasma metabolites. In a neonatal piglet model of perinatal hypoxia-ischemia, a systemic proinflammatory surge of cytokines has been identified after rewarming from therapeutic hypothermia. New biomarkers identified recently include osteopontin, activin A, neutrophil gelatinase-associated lipocalin, secretoneurin, Tau and neurofilament light protein. Brain-based biomarkers differ in their ability to predict short-term in-hospital outcomes and long-term neurologic deficits. Summary Neonatal brain biomarker research is currently in its very early development with major advances still to be made.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 199-203 |
| Number of pages | 5 |
| Journal | Current Opinion in Pediatrics |
| Volume | 30 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 1 2018 |
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Keywords
- cytokines
- digital ELISA
- metabolites
- neonatal brain injury
- outcomes
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Blood biomarkers for evaluation of perinatal encephalopathy : State of the art. / Graham, Ernest M; Everett, Allen D; Delpech, Jean Christophe; Northington, Frances.
In: Current Opinion in Pediatrics, Vol. 30, No. 2, 01.04.2018, p. 199-203.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Blood biomarkers for evaluation of perinatal encephalopathy
T2 - State of the art
AU - Graham, Ernest M
AU - Everett, Allen D
AU - Delpech, Jean Christophe
AU - Northington, Frances
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Purpose of review The rapid progress in biomarker science is on the threshold of significantly changing clinical care for infants in the neonatal ICU. Infants with neonatal brain injuries will likely be the first group whose management is dramatically altered with point-of-care, rapidly available brain biomarker analysis. Providing an interim update on progress in this area is the purpose of this review. Recent findings Highlighted findings from the past 18 months of publications on biomarkers in neonatal brain injury include; Specific nonbrain markers of cardiac health and global asphyxia continue to provide information on brain injury after hypoxic-ischemic encephalopathy (HIE). Prediction of injury in the piglet hypoxia-ischemia model is improved with the use of a combination score of plasma metabolites. In a neonatal piglet model of perinatal hypoxia-ischemia, a systemic proinflammatory surge of cytokines has been identified after rewarming from therapeutic hypothermia. New biomarkers identified recently include osteopontin, activin A, neutrophil gelatinase-associated lipocalin, secretoneurin, Tau and neurofilament light protein. Brain-based biomarkers differ in their ability to predict short-term in-hospital outcomes and long-term neurologic deficits. Summary Neonatal brain biomarker research is currently in its very early development with major advances still to be made.
AB - Purpose of review The rapid progress in biomarker science is on the threshold of significantly changing clinical care for infants in the neonatal ICU. Infants with neonatal brain injuries will likely be the first group whose management is dramatically altered with point-of-care, rapidly available brain biomarker analysis. Providing an interim update on progress in this area is the purpose of this review. Recent findings Highlighted findings from the past 18 months of publications on biomarkers in neonatal brain injury include; Specific nonbrain markers of cardiac health and global asphyxia continue to provide information on brain injury after hypoxic-ischemic encephalopathy (HIE). Prediction of injury in the piglet hypoxia-ischemia model is improved with the use of a combination score of plasma metabolites. In a neonatal piglet model of perinatal hypoxia-ischemia, a systemic proinflammatory surge of cytokines has been identified after rewarming from therapeutic hypothermia. New biomarkers identified recently include osteopontin, activin A, neutrophil gelatinase-associated lipocalin, secretoneurin, Tau and neurofilament light protein. Brain-based biomarkers differ in their ability to predict short-term in-hospital outcomes and long-term neurologic deficits. Summary Neonatal brain biomarker research is currently in its very early development with major advances still to be made.
KW - cytokines
KW - digital ELISA
KW - metabolites
KW - neonatal brain injury
KW - outcomes
UR - http://www.scopus.com/inward/record.url?scp=85044187415&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85044187415&partnerID=8YFLogxK
U2 - 10.1097/MOP.0000000000000591
DO - 10.1097/MOP.0000000000000591
M3 - Review article
C2 - 29346139
AN - SCOPUS:85044187415
VL - 30
SP - 199
EP - 203
JO - Current Opinion in Pediatrics
JF - Current Opinion in Pediatrics
SN - 1040-8703
IS - 2
ER -