Blockade of THC-seeking behavior and relapse in monkeys by the cannabinoid CB1-receptor antagonist rimonabant

Zuzana Justinova, Patrik Munzar, Leigh V. Panlilio, Sevil Yasar, Godfrey H. Redhi, Gianluigi Tanda, Steven R. Goldberg

Research output: Contribution to journalArticlepeer-review

Abstract

Accumulating evidence suggests the endocannabinoid system modulates environmental cues' ability to induce seeking of drugs, including nicotine and alcohol. However, little attention has been directed toward extending these advances to the growing problem of cannabis use disorders. Therefore, we studied intravenous self-administration of Δ9-tetrahydrocannabinol (THC), the main psychoactive constituent of marijuana, using a second-order schedule of drug seeking. Squirrel monkeys' lever responses produced only a brief cue light until the end of the session, when the final response delivered THC along with the cue. When a reinstatement procedure was used to model relapse following a period of abstinence, THC-seeking behavior was robustly reinstated by the cue or by pre-session administration of THC, other cannabinoid agonists, or morphine, but not cocaine. The cannabinoid antagonist rimonabant blocked cue-induced drug seeking, THC-induced drug seeking, and the direct reinforcing effects of THC. Thus, rimonabant and related medications might be effective as treatments for cannabinoid dependence.

Original languageEnglish (US)
Pages (from-to)2870-2877
Number of pages8
JournalNeuropsychopharmacology
Volume33
Issue number12
DOIs
StatePublished - Nov 2008

Keywords

  • Cannabinoids
  • Drug seeking
  • Reinstatement
  • Rimonabant
  • Second-order schedule
  • Self-administration

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Blockade of THC-seeking behavior and relapse in monkeys by the cannabinoid CB<sub>1</sub>-receptor antagonist rimonabant'. Together they form a unique fingerprint.

Cite this