TY - JOUR
T1 - Blockade of Rapid Axonal Transport
T2 - Effect of Intraocular Pressure Elevation in Primate Optic Nerve
AU - Quigley, Harry A.
AU - Guy, John
AU - Anderson, Douglas R.
PY - 1979/3
Y1 - 1979/3
N2 - After acute intraocular pressure (IOP) elevation, an induced disturbance of rapid axonal transport at the optic nerve head began within three hours at the IOP levels tested. The accumulation of radioactive label at the scleral lamina cribrosa increased with time of IOP elevation. There was a 60% decrease in the amount of transported material in the optic nerve, tract, and lateral geniculate body (LGN). Detailed analysis suggests that this decrease is not due to a simple slowdown of transport, but results from a total block of rapid transport in some axons, with no impairment in other axons. This total blockade of rapid transport by elevated IOP in involved axons differs from the apparent slowdown of transport in experimental papilledema, and the difference may explain the response of ganglion cells to the two conditions.
AB - After acute intraocular pressure (IOP) elevation, an induced disturbance of rapid axonal transport at the optic nerve head began within three hours at the IOP levels tested. The accumulation of radioactive label at the scleral lamina cribrosa increased with time of IOP elevation. There was a 60% decrease in the amount of transported material in the optic nerve, tract, and lateral geniculate body (LGN). Detailed analysis suggests that this decrease is not due to a simple slowdown of transport, but results from a total block of rapid transport in some axons, with no impairment in other axons. This total blockade of rapid transport by elevated IOP in involved axons differs from the apparent slowdown of transport in experimental papilledema, and the difference may explain the response of ganglion cells to the two conditions.
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U2 - 10.1001/archopht.1979.01020010269018
DO - 10.1001/archopht.1979.01020010269018
M3 - Article
C2 - 84662
AN - SCOPUS:0018348640
SN - 0003-9950
VL - 97
SP - 525
EP - 531
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 3
ER -