Blockade of feeding inhibition by neuromedin B using a selective receptor antagonist

Ellen Elizabeth Ladenheim, John E. Taylor, David H. Coy, Timothy H Moran

Research output: Contribution to journalArticle

Abstract

The ability of a selective neuromedin B receptor antagonist, D-Nal-cyclo[Cys-Tyr-D-Trp-Orn-Val-Cys]-Nal-NH2 (BIM-23127), to block suppression of food intake produced by the mammalian bombesin-like peptides neuromedin B and neuromedin C was examined. BIM-23127 completely blocked suppression of intake produced by neyromedin B but not by neuromedin C. These results suggest an independent role for neuromedin B receptors in suppression of food intake by bombesin-like peptides and demonstrate the utility of this group of antagonists for in vivo experiments.

Original languageEnglish (US)
JournalEuropean Journal of Pharmacology
Volume271
Issue number1
DOIs
StatePublished - Dec 12 1994

Fingerprint

Bombesin Receptors
Bombesin
Eating
Peptides
neuromedin B
BIM 23127
neuromedin C
peptide B

Keywords

  • Bombesin
  • Gastrin-releasing peptide
  • Neuromedin B

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Blockade of feeding inhibition by neuromedin B using a selective receptor antagonist. / Ladenheim, Ellen Elizabeth; Taylor, John E.; Coy, David H.; Moran, Timothy H.

In: European Journal of Pharmacology, Vol. 271, No. 1, 12.12.1994.

Research output: Contribution to journalArticle

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