Blockade of feeding inhibition by neuromedin B using a selective receptor antagonist

Ellen E. Ladenheim; John E. Taylor; David H. Coy; Timothy H. Moran

doi:10.1016/0014-2999(94)90291-7

Blockade of feeding inhibition by neuromedin B using a selective receptor antagonist

Ellen E. Ladenheim, John E. Taylor, David H. Coy, Timothy H. Moran

School of Medicine

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

The ability of a selective neuromedin B receptor antagonist, D-Nal-cyclo[Cys-Tyr-D-Trp-Orn-Val-Cys]-Nal-NH₂ (BIM-23127), to block suppression of food intake produced by the mammalian bombesin-like peptides neuromedin B and neuromedin C was examined. BIM-23127 completely blocked suppression of intake produced by neyromedin B but not by neuromedin C. These results suggest an independent role for neuromedin B receptors in suppression of food intake by bombesin-like peptides and demonstrate the utility of this group of antagonists for in vivo experiments.

Original language	English (US)
Pages (from-to)	R7-R9
Journal	European Journal of Pharmacology
Volume	271
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(94)90291-7
State	Published - Dec 12 1994

Keywords

Bombesin
Gastrin-releasing peptide
Neuromedin B

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(94)90291-7

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title = "Blockade of feeding inhibition by neuromedin B using a selective receptor antagonist",

abstract = "The ability of a selective neuromedin B receptor antagonist, D-Nal-cyclo[Cys-Tyr-D-Trp-Orn-Val-Cys]-Nal-NH2 (BIM-23127), to block suppression of food intake produced by the mammalian bombesin-like peptides neuromedin B and neuromedin C was examined. BIM-23127 completely blocked suppression of intake produced by neyromedin B but not by neuromedin C. These results suggest an independent role for neuromedin B receptors in suppression of food intake by bombesin-like peptides and demonstrate the utility of this group of antagonists for in vivo experiments.",

keywords = "Bombesin, Gastrin-releasing peptide, Neuromedin B",

author = "Ladenheim, {Ellen E.} and Taylor, {John E.} and Coy, {David H.} and Moran, {Timothy H.}",

note = "Funding Information: This research was partially supported by a grant from the National Institutes of Health (DK 46448).",

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doi = "10.1016/0014-2999(94)90291-7",

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T1 - Blockade of feeding inhibition by neuromedin B using a selective receptor antagonist

AU - Ladenheim, Ellen E.

AU - Taylor, John E.

AU - Coy, David H.

AU - Moran, Timothy H.

N1 - Funding Information: This research was partially supported by a grant from the National Institutes of Health (DK 46448).

PY - 1994/12/12

Y1 - 1994/12/12

N2 - The ability of a selective neuromedin B receptor antagonist, D-Nal-cyclo[Cys-Tyr-D-Trp-Orn-Val-Cys]-Nal-NH2 (BIM-23127), to block suppression of food intake produced by the mammalian bombesin-like peptides neuromedin B and neuromedin C was examined. BIM-23127 completely blocked suppression of intake produced by neyromedin B but not by neuromedin C. These results suggest an independent role for neuromedin B receptors in suppression of food intake by bombesin-like peptides and demonstrate the utility of this group of antagonists for in vivo experiments.

AB - The ability of a selective neuromedin B receptor antagonist, D-Nal-cyclo[Cys-Tyr-D-Trp-Orn-Val-Cys]-Nal-NH2 (BIM-23127), to block suppression of food intake produced by the mammalian bombesin-like peptides neuromedin B and neuromedin C was examined. BIM-23127 completely blocked suppression of intake produced by neyromedin B but not by neuromedin C. These results suggest an independent role for neuromedin B receptors in suppression of food intake by bombesin-like peptides and demonstrate the utility of this group of antagonists for in vivo experiments.

KW - Bombesin

KW - Gastrin-releasing peptide

KW - Neuromedin B

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Blockade of feeding inhibition by neuromedin B using a selective receptor antagonist

Abstract

Keywords

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