Blockade of feeding inhibition by neuromedin B using a selective receptor antagonist

Ellen E. Ladenheim, John E. Taylor, David H. Coy, Timothy H. Moran

Research output: Contribution to journalArticlepeer-review

Abstract

The ability of a selective neuromedin B receptor antagonist, D-Nal-cyclo[Cys-Tyr-D-Trp-Orn-Val-Cys]-Nal-NH2 (BIM-23127), to block suppression of food intake produced by the mammalian bombesin-like peptides neuromedin B and neuromedin C was examined. BIM-23127 completely blocked suppression of intake produced by neyromedin B but not by neuromedin C. These results suggest an independent role for neuromedin B receptors in suppression of food intake by bombesin-like peptides and demonstrate the utility of this group of antagonists for in vivo experiments.

Original languageEnglish (US)
Pages (from-to)R7-R9
JournalEuropean Journal of Pharmacology
Volume271
Issue number1
DOIs
StatePublished - Dec 12 1994

Keywords

  • Bombesin
  • Gastrin-releasing peptide
  • Neuromedin B

ASJC Scopus subject areas

  • Pharmacology

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