Blockade of central GLP-1 receptors prevents CART-induced hypophagia and brain c-Fos expression

Susan Aja, Cassandra Ewing, Jennifer Lin, Jayson Hyun, Timothy H. Moran

Research output: Contribution to journalArticle

Abstract

Central administration of both CART and GLP-1 reduces feeding and increases c-Fos in brain areas associated with food intake. To determine whether aspects of CART's effects were mediated through GLP-1's action, we examined whether the GLP-1 receptor antagonist des-His1-Glu9-exendin-4 (EX) blocked CART-induced feeding inhibition, and c-Fos activation. An i.c.v. dose of 100 μg EX blocked the feeding inhibitory action of 1 μg of CART i.c.v. and prevented CART-induced c-Fos expression at multiple hindbrain and hypothalamic sites. These data suggest that i.c.v. CART administration activates a central release of GLP-1 to inhibit feeding and produce widespread neural activation.

Original languageEnglish (US)
Pages (from-to)157-164
Number of pages8
JournalPeptides
Volume27
Issue number1
DOIs
StatePublished - Jan 1 2006

Keywords

  • Cocaine-amphetamine-regulated transcript
  • Exendin
  • Food intake
  • Glucagon-like peptide-1
  • Hindbrain
  • c-Fos

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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