Blockade of central GLP-1 receptors prevents CART-induced hypophagia and brain c-Fos expression

Susan Aja; Cassandra Ewing; Jennifer Lin; Jayson Hyun; Timothy H. Moran

doi:10.1016/j.peptides.2005.07.003

Blockade of central GLP-1 receptors prevents CART-induced hypophagia and brain c-Fos expression

Susan Aja, Cassandra Ewing, Jennifer Lin, Jayson Hyun, Timothy H. Moran

School of Medicine

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Central administration of both CART and GLP-1 reduces feeding and increases c-Fos in brain areas associated with food intake. To determine whether aspects of CART's effects were mediated through GLP-1's action, we examined whether the GLP-1 receptor antagonist des-His₁-Glu₉-exendin-4 (EX) blocked CART-induced feeding inhibition, and c-Fos activation. An i.c.v. dose of 100 μg EX blocked the feeding inhibitory action of 1 μg of CART i.c.v. and prevented CART-induced c-Fos expression at multiple hindbrain and hypothalamic sites. These data suggest that i.c.v. CART administration activates a central release of GLP-1 to inhibit feeding and produce widespread neural activation.

Original language	English (US)
Pages (from-to)	157-164
Number of pages	8
Journal	Peptides
Volume	27
Issue number	1
DOIs	https://doi.org/10.1016/j.peptides.2005.07.003
State	Published - Jan 2006

Keywords

Cocaine-amphetamine-regulated transcript
Exendin
Food intake
Glucagon-like peptide-1
Hindbrain
c-Fos

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/j.peptides.2005.07.003

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title = "Blockade of central GLP-1 receptors prevents CART-induced hypophagia and brain c-Fos expression",

abstract = "Central administration of both CART and GLP-1 reduces feeding and increases c-Fos in brain areas associated with food intake. To determine whether aspects of CART's effects were mediated through GLP-1's action, we examined whether the GLP-1 receptor antagonist des-His1-Glu9-exendin-4 (EX) blocked CART-induced feeding inhibition, and c-Fos activation. An i.c.v. dose of 100 μg EX blocked the feeding inhibitory action of 1 μg of CART i.c.v. and prevented CART-induced c-Fos expression at multiple hindbrain and hypothalamic sites. These data suggest that i.c.v. CART administration activates a central release of GLP-1 to inhibit feeding and produce widespread neural activation.",

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AU - Aja, Susan

AU - Ewing, Cassandra

AU - Lin, Jennifer

AU - Hyun, Jayson

AU - Moran, Timothy H.

PY - 2006/1

Y1 - 2006/1

N2 - Central administration of both CART and GLP-1 reduces feeding and increases c-Fos in brain areas associated with food intake. To determine whether aspects of CART's effects were mediated through GLP-1's action, we examined whether the GLP-1 receptor antagonist des-His1-Glu9-exendin-4 (EX) blocked CART-induced feeding inhibition, and c-Fos activation. An i.c.v. dose of 100 μg EX blocked the feeding inhibitory action of 1 μg of CART i.c.v. and prevented CART-induced c-Fos expression at multiple hindbrain and hypothalamic sites. These data suggest that i.c.v. CART administration activates a central release of GLP-1 to inhibit feeding and produce widespread neural activation.

AB - Central administration of both CART and GLP-1 reduces feeding and increases c-Fos in brain areas associated with food intake. To determine whether aspects of CART's effects were mediated through GLP-1's action, we examined whether the GLP-1 receptor antagonist des-His1-Glu9-exendin-4 (EX) blocked CART-induced feeding inhibition, and c-Fos activation. An i.c.v. dose of 100 μg EX blocked the feeding inhibitory action of 1 μg of CART i.c.v. and prevented CART-induced c-Fos expression at multiple hindbrain and hypothalamic sites. These data suggest that i.c.v. CART administration activates a central release of GLP-1 to inhibit feeding and produce widespread neural activation.

KW - Cocaine-amphetamine-regulated transcript

KW - Exendin

KW - Food intake

KW - Glucagon-like peptide-1

KW - Hindbrain

KW - c-Fos

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Blockade of central GLP-1 receptors prevents CART-induced hypophagia and brain c-Fos expression

Abstract

Keywords

ASJC Scopus subject areas

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