Blockade of acetylcholine receptors: A model of myasthenia gravis

S. Satyamurti, Daniel B. Drachman, Fred Slone

Research output: Contribution to journalArticle

Abstract

In order to block acetylcholine receptors of muscle, the alpha toxin of the Formosan cobra (Naja naja atra) was given intraveonously to rats. Electrophysiological and pharmacological changes typical of myasthenia gravis were recorded, including decremental responses to repetitive stimuli, curare sensitivity, neostigmine reversal, and posttetanic phenomena. This model supports the concept that a reduction of available acetylcholine receptors may play an important role in myasthenia gravis.

Original languageEnglish (US)
Pages (from-to)955-957
Number of pages3
JournalScience
Volume187
Issue number4180
DOIs
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • General

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