BLOCKADE BY YOHIMBINE OF PRAZOSIN‐RESISTANT PRESSOR EFFECTS OF ADRENALINE IN THE PITHED RAT

N. A. FLAVAHAN, J. C. McGRATH

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Abstract

In the pithed rat, following β‐adrenoceptor blockade, the pressor effect of adrenaline can be blocked by phentolamine or by prazosin plus yohimbine but not by prazosin or yohimbine given alone. It is concluded that adrenaline produces its pressor effect by acting on two sets of post‐junctional α‐adrenoceptors, each of which is sensitive to phentolamine, one of which is sensitive to prazosin but resistant to yohimbine and the other of which is sensitive to yohimbine but resistant to prazosin. 1980 British Pharmacological Society

Original languageEnglish (US)
Pages (from-to)355-357
Number of pages3
JournalBritish Journal of Pharmacology
Volume69
Issue number3
DOIs
StatePublished - Jul 1980

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ASJC Scopus subject areas

  • Pharmacology

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