Abstract
Chemiluminescence often accompanies the spontaneous degradation of intermediates in an electronically excited state. The interaction of iron with bleomycin results in the activation of bleomycin to a reactive intermediate which can alter DNA or undergo self-inactivation. This report demonstrates that the interaction of ferrous iron with bleomycin results in chemiluminescence, that this response is iron-specific and that the presence of DNA prevents the generation of chemiluminescence. These observations suggest that the activated bleomycin intermediate may be in an electronically excited state.
Original language | English (US) |
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Pages (from-to) | 378-383 |
Number of pages | 6 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 112 |
Issue number | 2 |
DOIs | |
State | Published - Apr 29 1983 |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology