Bleomycin-metal interaction: Ferrous iron-initiated chemiluminescence

M. A. Trush, E. G. Mimnaugh, Z. H. Siddik, T. E. Gram

Research output: Contribution to journalArticle

Abstract

Chemiluminescence often accompanies the spontaneous degradation of intermediates in an electronically excited state. The interaction of iron with bleomycin results in the activation of bleomycin to a reactive intermediate which can alter DNA or undergo self-inactivation. This report demonstrates that the interaction of ferrous iron with bleomycin results in chemiluminescence, that this response is iron-specific and that the presence of DNA prevents the generation of chemiluminescence. These observations suggest that the activated bleomycin intermediate may be in an electronically excited state.

Original languageEnglish (US)
Pages (from-to)378-383
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume112
Issue number2
DOIs
StatePublished - Apr 29 1983

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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