Bleeding and Thrombosis with Pediatric Extracorporeal Life Support: A Roadmap for Management, Research, and the Future from the Pediatric Cardiac Intensive Care Society: Part 2∗

Jamie S. Penk, Sushma Reddy, Angelo Polito, Michael J. Cisco, Catherine K. Allan, Melania Bembea, Therese M. Giglia, Henry H. Cheng, Ravi R. Thiagarajan, Heidi J. Dalton

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To make recommendations on improving understanding of bleeding and thrombosis with pediatric extracorporeal life support including future research directions. Data Sources: Evaluation of literature and consensus conferences of pediatric critical care and extracorporeal life support experts. Study Selection: A team of 10 experts with pediatric cardiac and extracorporeal membrane oxygenation experience and expertise met through the Pediatric Cardiac Intensive Care Society to review current knowledge and make recommendations for future research to establish "best practice" for anticoagulation management related to extracorporeal life support. Data Extraction/Data Synthesis: This white paper focuses on clinical understanding and limitations of current strategies to monitor anticoagulation. For each test of anticoagulation, limitations of current knowledge are addressed and future research directions suggested. Conclusions: No consensus on best practice for anticoagulation monitoring exists. Structured scientific evaluation to answer questions regarding anticoagulation monitoring and bleeding and thrombotic events should occur in multicenter studies using standardized approaches and well-defined endpoints. Outcomes related to need for component change, blood product administration, healthcare outcome, and economic assessment should be incorporated into studies. All centers should report data on patient receiving extracorporeal life support to a registry.

Original languageEnglish (US)
Pages (from-to)1034-1039
Number of pages6
JournalPediatric Critical Care Medicine
Volume20
Issue number11
DOIs
StatePublished - Nov 1 2019

Keywords

  • anticoagulation
  • extracorporeal membrane oxygenation
  • hemorrhage
  • monitoring
  • pediatrics
  • thrombosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Critical Care and Intensive Care Medicine

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