Blast TBI models, neuropathology, and implications for seizure risk

S. Krisztian Kovacs, Fabio Leonessa, Geoffrey S.F. Ling

Research output: Contribution to journalReview articlepeer-review

Abstract

Traumatic brain injury (TBI) due to explosive blast exposure is a leading combat casualty. It is also implicated as a key contributor to war related mental health diseases. A clinically important consequence of all types of TBI is a high risk for development of seizures and epilepsy. Seizures have been reported in patients who have suffered blast injuries in the Global War on Terror but the exact prevalence is unknown. The occurrence of seizures supports the contention that explosive blast leads to both cellular and structural brain pathology. Unfortunately, the exact mechanism by which explosions cause brain injury is unclear, which complicates development of meaningful therapies and mitigation strategies. To help improve understanding, detailed neuropathological analysis is needed. For this, histopathological techniques are extremely valuable and indispensable. In the following we will review the pathological results, including those from immunohistochemical and special staining approaches, from recent preclinical explosive blast studies.

Original languageEnglish (US)
Article numberArticle 47
JournalFrontiers in Neurology
Volume5 APR
DOIs
StatePublished - 2014

Keywords

  • Animal models
  • Blast
  • Histopathology
  • Neuropathology
  • Post-traumatic epilepsy
  • Seizures
  • Tissue processing
  • Traumatic brain injury

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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