Bladder/lung cancer mortality in Blackfoot-disease (BFD)-endemic area villages with low (

Steven H. Lamm, Shayhan A. Robbins, Chao Zhou, Jun Lu, Rusan Chen, Manning Feinleib

Research output: Contribution to journalArticle

Abstract

Objective: To examine the analytic role of arsenic exposure on cancer mortality among the low-dose (well water arsenic level 500 μg/L, but use of the village mean or the maximum did not. Poisson analyses using mean or maximum arsenic levels showed significant negative cancer slope factors for models of bladder cancers and of bladder and lung cancers combined. Inclusion of the southwest Taiwan regional data did not change the findings when the model contained an explanatory variable for non-arsenic differences. A positive slope could only be generated by including the comparison population as a separate data point with the assumption of zero arsenic exposure from drinking water and eliminating the variable for non-arsenic risk factors. Conclusion: The cancer rates are higher among the low-dose (

Original languageEnglish (US)
Pages (from-to)147-156
Number of pages10
JournalRegulatory Toxicology and Pharmacology
Volume65
Issue number1
DOIs
StatePublished - Feb 2013

Keywords

  • Arsenic
  • Blackfoot-disease area
  • Bladder cancer
  • Dose-response
  • Lung cancer

ASJC Scopus subject areas

  • Toxicology

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