Bladder complications in patients receiving cyclophosphamide for systemic lupus erythematosus or rheumatoid arthritis

P. H. Plotz; J. H. Klippel; J. L. Decker; D. Grauman; B. Wolff; B. C. Brown; G. Rutt

Bladder complications in patients receiving cyclophosphamide for systemic lupus erythematosus or rheumatoid arthritis

P. H. Plotz, J. H. Klippel, J. L. Decker, D. Grauman, B. Wolff, B. C. Brown, G. Rutt

Research output: Contribution to journal › Article › peer-review

Abstract

The bladder complications of 54 patients treated with oral cyclophosphamide for systemic lupus erythematosus (43) or rheumatoid arthritis (11) were reviewed. During an observation period of 241 patient years, we saw 7 cases of acute hemorrhagic cystitis and 2 cases of transitional cell carcinoma of the bladder. Bladder carcinoma was identified 28 and 60 months after withdrawal of the drug and resulted in the death of one patient. The late-occurring serious toxicities of cyclophosphamide should limit the use of the drug in the treatment of nonmalignant inflammatory rheumatic conditions.

Original language	English (US)
Pages (from-to)	221-223
Number of pages	3
Journal	Annals of Internal Medicine
Volume	91
Issue number	2
State	Published - 1979
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Bladder complications in patients receiving cyclophosphamide for systemic lupus erythematosus or rheumatoid arthritis",

abstract = "The bladder complications of 54 patients treated with oral cyclophosphamide for systemic lupus erythematosus (43) or rheumatoid arthritis (11) were reviewed. During an observation period of 241 patient years, we saw 7 cases of acute hemorrhagic cystitis and 2 cases of transitional cell carcinoma of the bladder. Bladder carcinoma was identified 28 and 60 months after withdrawal of the drug and resulted in the death of one patient. The late-occurring serious toxicities of cyclophosphamide should limit the use of the drug in the treatment of nonmalignant inflammatory rheumatic conditions.",

author = "Plotz, {P. H.} and Klippel, {J. H.} and Decker, {J. L.} and D. Grauman and B. Wolff and Brown, {B. C.} and G. Rutt",

year = "1979",

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T1 - Bladder complications in patients receiving cyclophosphamide for systemic lupus erythematosus or rheumatoid arthritis

AU - Plotz, P. H.

AU - Klippel, J. H.

AU - Decker, J. L.

AU - Grauman, D.

AU - Wolff, B.

AU - Brown, B. C.

AU - Rutt, G.

PY - 1979

Y1 - 1979

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AB - The bladder complications of 54 patients treated with oral cyclophosphamide for systemic lupus erythematosus (43) or rheumatoid arthritis (11) were reviewed. During an observation period of 241 patient years, we saw 7 cases of acute hemorrhagic cystitis and 2 cases of transitional cell carcinoma of the bladder. Bladder carcinoma was identified 28 and 60 months after withdrawal of the drug and resulted in the death of one patient. The late-occurring serious toxicities of cyclophosphamide should limit the use of the drug in the treatment of nonmalignant inflammatory rheumatic conditions.

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JO - Annals of Internal Medicine

JF - Annals of Internal Medicine

IS - 2

ER -

Bladder complications in patients receiving cyclophosphamide for systemic lupus erythematosus or rheumatoid arthritis

Abstract

ASJC Scopus subject areas

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