Bladder cancer stem cells

Mai N. Tran, Jinesh G. Goodwin, David McConkey, Ashish M. Kamat

Research output: Contribution to journalReview article

Abstract

Stem cells are undifferentiated cells that renew themselves while simultaneously producing differentiated tissue- or organspecific cells through asymmetric cell division. The appreciation of the importance of stem cells in normal tissue biology has prompted the idea that cancers may also develop from a progenitor pool (the "cancer stem cell (CSC) hypothesis"), and this idea is gaining increasing acceptance among scientists. CSCs are sub-populations of cancer cells responsible for tumor initiation, differentiation, recurrence, metastasis, and drug resistance. First identified in the hematopoietic system, CSCs have also been discovered in solid tumors of the breast, colon, pancreas, and brain. Recently, the tissue-specific stem cells of the normal urothelium have been proposed to reside in the basal layer, and investigators have isolated phenotypically similar populations of cells from urothelial cancer cell lines and primary tumors. Herein, we review the CSC hypothesis and apply it to explain the development of the two different types of bladder cancer: Noninvasive ("superficial") carcinoma and invasive carcinoma. We also examine potential approaches to identify CSCs in bladder cancer as well as therapeutic applications of these findings. While exciting, the verification of the existence of CSCs in bladder cancer raises several new questions. Herein, we identify and answer some of these questions to help readers better understand bladder cancer development and identify reasonable therapeutic strategy for targeting stem cells.

Original languageEnglish (US)
Pages (from-to)387-395
Number of pages9
JournalCurrent Stem Cell Research and Therapy
Volume5
Issue number4
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Neoplastic Stem Cells
Urinary Bladder Neoplasms
Stem Cells
Neoplasms
Asymmetric Cell Division
Carcinoma
Hematopoietic System
Urothelium
Tumor Cell Line
Drug Resistance
Population
Pancreas
Colon
Research Personnel
Breast Neoplasms
Neoplasm Metastasis
Recurrence
Brain
Therapeutics

Keywords

  • Bladder cancer
  • Cancer stem cell
  • EMT
  • miRNA
  • Muscle invasive
  • Superficial

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Bladder cancer stem cells. / Tran, Mai N.; Goodwin, Jinesh G.; McConkey, David; Kamat, Ashish M.

In: Current Stem Cell Research and Therapy, Vol. 5, No. 4, 2010, p. 387-395.

Research output: Contribution to journalReview article

Tran, Mai N. ; Goodwin, Jinesh G. ; McConkey, David ; Kamat, Ashish M. / Bladder cancer stem cells. In: Current Stem Cell Research and Therapy. 2010 ; Vol. 5, No. 4. pp. 387-395.
@article{b4e7761f48d6488da59f4f90fbd22527,
title = "Bladder cancer stem cells",
abstract = "Stem cells are undifferentiated cells that renew themselves while simultaneously producing differentiated tissue- or organspecific cells through asymmetric cell division. The appreciation of the importance of stem cells in normal tissue biology has prompted the idea that cancers may also develop from a progenitor pool (the {"}cancer stem cell (CSC) hypothesis{"}), and this idea is gaining increasing acceptance among scientists. CSCs are sub-populations of cancer cells responsible for tumor initiation, differentiation, recurrence, metastasis, and drug resistance. First identified in the hematopoietic system, CSCs have also been discovered in solid tumors of the breast, colon, pancreas, and brain. Recently, the tissue-specific stem cells of the normal urothelium have been proposed to reside in the basal layer, and investigators have isolated phenotypically similar populations of cells from urothelial cancer cell lines and primary tumors. Herein, we review the CSC hypothesis and apply it to explain the development of the two different types of bladder cancer: Noninvasive ({"}superficial{"}) carcinoma and invasive carcinoma. We also examine potential approaches to identify CSCs in bladder cancer as well as therapeutic applications of these findings. While exciting, the verification of the existence of CSCs in bladder cancer raises several new questions. Herein, we identify and answer some of these questions to help readers better understand bladder cancer development and identify reasonable therapeutic strategy for targeting stem cells.",
keywords = "Bladder cancer, Cancer stem cell, EMT, miRNA, Muscle invasive, Superficial",
author = "Tran, {Mai N.} and Goodwin, {Jinesh G.} and David McConkey and Kamat, {Ashish M.}",
year = "2010",
doi = "10.2174/157488810793351640",
language = "English (US)",
volume = "5",
pages = "387--395",
journal = "Current Stem Cell Research and Therapy",
issn = "1574-888X",
publisher = "Bentham Science Publishers B.V.",
number = "4",

}

TY - JOUR

T1 - Bladder cancer stem cells

AU - Tran, Mai N.

AU - Goodwin, Jinesh G.

AU - McConkey, David

AU - Kamat, Ashish M.

PY - 2010

Y1 - 2010

N2 - Stem cells are undifferentiated cells that renew themselves while simultaneously producing differentiated tissue- or organspecific cells through asymmetric cell division. The appreciation of the importance of stem cells in normal tissue biology has prompted the idea that cancers may also develop from a progenitor pool (the "cancer stem cell (CSC) hypothesis"), and this idea is gaining increasing acceptance among scientists. CSCs are sub-populations of cancer cells responsible for tumor initiation, differentiation, recurrence, metastasis, and drug resistance. First identified in the hematopoietic system, CSCs have also been discovered in solid tumors of the breast, colon, pancreas, and brain. Recently, the tissue-specific stem cells of the normal urothelium have been proposed to reside in the basal layer, and investigators have isolated phenotypically similar populations of cells from urothelial cancer cell lines and primary tumors. Herein, we review the CSC hypothesis and apply it to explain the development of the two different types of bladder cancer: Noninvasive ("superficial") carcinoma and invasive carcinoma. We also examine potential approaches to identify CSCs in bladder cancer as well as therapeutic applications of these findings. While exciting, the verification of the existence of CSCs in bladder cancer raises several new questions. Herein, we identify and answer some of these questions to help readers better understand bladder cancer development and identify reasonable therapeutic strategy for targeting stem cells.

AB - Stem cells are undifferentiated cells that renew themselves while simultaneously producing differentiated tissue- or organspecific cells through asymmetric cell division. The appreciation of the importance of stem cells in normal tissue biology has prompted the idea that cancers may also develop from a progenitor pool (the "cancer stem cell (CSC) hypothesis"), and this idea is gaining increasing acceptance among scientists. CSCs are sub-populations of cancer cells responsible for tumor initiation, differentiation, recurrence, metastasis, and drug resistance. First identified in the hematopoietic system, CSCs have also been discovered in solid tumors of the breast, colon, pancreas, and brain. Recently, the tissue-specific stem cells of the normal urothelium have been proposed to reside in the basal layer, and investigators have isolated phenotypically similar populations of cells from urothelial cancer cell lines and primary tumors. Herein, we review the CSC hypothesis and apply it to explain the development of the two different types of bladder cancer: Noninvasive ("superficial") carcinoma and invasive carcinoma. We also examine potential approaches to identify CSCs in bladder cancer as well as therapeutic applications of these findings. While exciting, the verification of the existence of CSCs in bladder cancer raises several new questions. Herein, we identify and answer some of these questions to help readers better understand bladder cancer development and identify reasonable therapeutic strategy for targeting stem cells.

KW - Bladder cancer

KW - Cancer stem cell

KW - EMT

KW - miRNA

KW - Muscle invasive

KW - Superficial

UR - http://www.scopus.com/inward/record.url?scp=78650004802&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650004802&partnerID=8YFLogxK

U2 - 10.2174/157488810793351640

DO - 10.2174/157488810793351640

M3 - Review article

C2 - 20955163

AN - SCOPUS:78650004802

VL - 5

SP - 387

EP - 395

JO - Current Stem Cell Research and Therapy

JF - Current Stem Cell Research and Therapy

SN - 1574-888X

IS - 4

ER -